ArticleProceedings of the National Academy of Sciences of the United States of America2009
Ubiquitous internal gene duplication and intron creation in eukaryotes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The Role of Small Segmental Duplications in Generating Identical Isoforms Through Alternative Splicing Sites.Biochemical genetics · 2026Article
- De Novo Creation of Two Novel Spliceosomal Introns of RECG1 by Intronization of Formerly Exonic Sequences in Orchidaceae.Journal of molecular evolution · 2025Article
- Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture.Microorganisms · 2022Article
- Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans.Nature ecology & evolution · 2022Article
- Restriction of an intron size en route to endothermy.Nucleic acids research · 2021Article
- The genomic structure of the highly-conserved dmrt1 gene in Solea senegalensis (Kaup, 1868) shows an unexpected intragenic duplication.PloS one · 2020Article
- Association Study of the 5'UTR Intron of theFrontiers in plant science · 2020Article
- Genome wide analysis of the transition to pathogenic lifestyles in Magnaporthales fungi.Scientific reports · 2018Article
- Genotyping and Bio-Sensing Chemosensory Proteins in Insects.Sensors (Basel, Switzerland) · 2017Review
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- Imprecise intron losses are less frequent than precise intron losses but are not rare in plants.Biology direct · 2015Article
- Origins and impacts of new mammalian exons.Cell reports · 2015Article
- Evolution of a Novel Antiviral Immune-Signaling Interaction by Partial-Gene Duplication.PloS one · 2015Article
- Intron evolution in Saccharomycetaceae.Genome biology and evolution · 2014Article
- Characterization of newly gained introns in Daphnia populations.Genome biology and evolution · 2014Article
- Novel microRNA families expanded in the human genome.BMC genomics · 2013Article
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- Functional and evolutionary analysis of the genome of an obligate fungal symbiont.Genome biology and evolution · 2013Article
- Spliced DNA sequences in the Paramecium germline: their properties and evolutionary potential.Genome biology and evolution · 2013Article
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2 authors.
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Abstract
Duplication of genomic segments provides a primary resource for the origin of evolutionary novelties. However, most previous studies have focused on duplications of complete protein-coding genes, whereas little is known about the significance of duplication segments that are entirely internal to genes. Our examination of six fully sequenced genomes reveals that internal duplications of gene segments occur at a high frequency (0.001-0.013 duplications/gene per million years), similar to that of complete gene duplications, such that 8-17% of the genes in a genome carry duplicated intronic and/or exonic regions. At least 7-30% of such genes have acquired novel introns, either because a prior intron in the same gene has been duplicated, or more commonly, because a spatial change has activated a latent splice site. These results strongly suggest a major evolutionary role for internal gene duplications in the origin of genomic novelties, particularly as a mechanism for intron gain.
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