ArticleArteriosclerosis, thrombosis, and vascular biology2010
Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Regulatory T cells suppress the expression of COX-2 in vulnerable plaque.Heart and vessels · 2020Article
- Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression.Journal of cellular and molecular medicine · 2019Article
- Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury.JCI insight · 2018Article
- Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice.Clinical immunology (Orlando, Fla.) · 2014Article
- Cell-type-specific roles for COX-2 in UVB-induced skin cancer.Carcinogenesis · 2014Article
- Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge.Journal of neuroscience research · 2014Article
- Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice.PloS one · 2014Article
- Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury.Journal of inflammation research · 2014Article
- Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western diet.Molecular genetics and metabolism · 2012Article
- UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Article
- Targeted deletions of cyclooxygenase-2 and atherogenesis in mice.Circulation · 2010Article
- Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe role of myeloid cell cyclooxygenase-2 (COX-2) in the progression of atherosclerosis has not been clearly defined. METHODS AND
resultsWe investigated the role of COX-2 expressed in the myeloid lineage in the development of atherosclerosis using a myeloid-specific COX-2(-/-) (COX-2(-M/-M)) mouse on a hyperlipidemic apolipoprotein (apo) E(-/-) background (COX-2(-M/-M)/apoE(-/-)). Myeloid COX-2 depletion resulted in significant attenuation of acute inflammation corresponding with decreased PGE(2) levels in an air pouch model. COX-2 depletion in myeloid cells did not influence development of atherosclerosis in COX-2(-M/-M)/apoE(-/-) when compared to apoE(-/-) littermates fed either chow or western diets. The unanticipated lack of contribution of myeloid COX-2 to the development atherosclerosis is not attributable to altered maintenance, differentiation, or mobilization of myeloid and lymphoid populations. Moreover, myeloid COX-2 depletion resulted in unaltered serum prostanoid levels and cellular composition of atherosclerotic lesions of COX-2(-M/-M)/apoE(-/-) mice.
conclusionsOur results suggest that COX-2 expression in myeloid cells, including macrophages, does not influence the development of atherosclerosis in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.