ReviewJournal of applied physiology (Bethesda, Md. : 1985)2010
Obesity, adipokines, and lung disease.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 162 citations in OpenAlex.
- Trial
- Association Between Serum Leptin Concentrations and Disease Severity Across Airway Disease Phenotypes: A Single-Center Retrospective Observational Study.Diseases (Basel, Switzerland) · 2026Article
- Effect of metformin on airway inflammation in obese asthmatic mice and study of the mechanism involved.Scientific reports · 2025Article
- Effects of Short-Term Exposure to High-Dose Inhaled Corticosteroids on Appetite, Dietary Intake, Leptin Levels, and Body Weight in Adults with Asthma-A Prospective Pilot Study.Journal of personalized medicine · 2025Article
- Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma.Animals : an open access journal from MDPI · 2025Article
- Acute pulmonary edema after subarachnoid hemorrhage: risk factors and comorbidities-an analysis of a nationwide database from the United States.Journal of intensive care · 2025Article
- Serum leptin and adiponectin function as indicators of allergic sensitization in pediatric adenotonsillar hypertrophy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Sleeve Gastrectomy is Associated with Longitudinal Improvements in Lung Function and Patient-Reported Respiratory Outcomes.Obesity surgery · 2024Article
- Asthma prevalence among United States population insights from NHANES data analysis.Scientific reports · 2024Article
- Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample.The open respiratory medicine journal · 2024Article
- Radiomic phenotyping of the lung parenchyma in a lung cancer screening cohort.Scientific reports · 2023Article
- Leptin and Asthma: What Are the Interactive Correlations?Biomolecules · 2022Review
- Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study.BMC rheumatology · 2022Article
- Association of obesity-related inflammatory pathways with lung function and exercise capacity.Respiratory medicine · 2021Article
- An American Physiological Society cross-journal Call for Papers on "Inter-Organ Communication in Homeostasis and Disease".American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Adiponectin Inhibits the Production of TNF-α, IL-6 and Chemokines by Human Lung Macrophages.Frontiers in pharmacology · 2021Article
- Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview.Metabolites · 2020Review
- Somatotypes trajectories during adulthood and their association with COPD phenotypes.ERJ open research · 2020Article
- Pulmonary vascular dysfunction in metabolic syndrome.The Journal of physiology · 2019Review
- Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).Respiratory research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This review summarizes the state of the current literature relating to the associations of lung disease on obesity and adipokines (proteins produced by adipose tissue) in humans. Obesity is an independent risk factor for asthma. Recent studies suggest that obesity is also an independent risk factor for chronic airflow obstruction, as is seen with chronic obstructive pulmonary disease (COPD). The mechanistic basis for these associations in humans is not established, although a possible role for adipokines has been invoked. Leptin, a proinflammatory adipokine, and adiponectin, an anti-inflammatory adipokine, are causally associated with asthma in mice. Although human studies are currently inconclusive, high-serum leptin and low-serum adiponectin concentrations predict asthma, independent of obesity, in select population groups, such as premenopausal women in the United States. In contradistinction, low-serum leptin and high-serum adiponectin concentrations are associated with stable COPD, although these associations are likely confounded by fat mass. Interestingly, leptin may promote systemic and airway inflammation in stable COPD patients. On the other hand, COPD may upregulate systemic and lung adiponectin expression. The precise mechanism and significance of the associations between these adipokines and lung disease at the current stage is confusing and frankly paradoxical in places. This area of research needs additional study that may open up novel therapeutic strategies for these lung diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.