ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2010
High-resolution entrainment mapping of gastric pacing: a new analytical tool.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Systematic review of small intestine pacing parameters for modulation of gut function.Neurogastroenterology and motility · 2023Pooled it
- Patterns of Abnormal Gastric Pacemaking After Sleeve Gastrectomy Defined by Laparoscopic High-Resolution Electrical Mapping.Obesity surgery · 2017Trial
- Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics.Diabetes care · 2013Trial
- Optical Mapping of Pacing-Elicited Slow Waves in the Swine Stomach: Role of Virtual Electrodes.Neurogastroenterology and motility · 2026Article
- [A New Paradigm in Diagnosing Functional Gastroduodenal Disorders: High-Resolution Electrogastrography].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Review
- Optimization of pacing parameters to entrain slow wave activity in the pig jejunum.Scientific reports · 2024Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- A Miniature Configurable Wireless System for Recording Gastric Electrophysiological Activity and Delivering High-Energy Electrical Stimulation.IEEE journal on emerging and selected topics in circuits and systems · 2018Article
- A novel retractable laparoscopic device for mapping gastrointestinal slow wave propagation patterns.Surgical endoscopy · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity.IEEE transactions on bio-medical engineering · 2017Article
- Acute Slow Wave Responses to High-Frequency Gastric Electrical Stimulation in Patients With Gastroparesis Defined by High-Resolution Mapping.Neuromodulation : journal of the International Neuromodulation Society · 2016Article
- A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.Mathematical medicine and biology : a journal of the IMA · 2015Article
- A Multiscale Tridomain Model for Simulating Bioelectric Gastric Pacing.IEEE transactions on bio-medical engineering · 2015Article
- Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting.Gastroenterology · 2015Article
- Regulation of gastric electrical and mechanical activity by cholinesterases in mice.Journal of neurogastroenterology and motility · 2015Article
- Gastric arrhythmias in gastroparesis: low- and high-resolution mapping of gastric electrical activity.Gastroenterology clinics of North America · 2015Review
- Slow wave conduction patterns in the stomach: from Waller's foundations to current challenges.Acta physiologica (Oxford, England) · 2015Review
- A system and method for online high-resolution mapping of gastric slow-wave activity.IEEE transactions on bio-medical engineering · 2014Article
- Recent progress in gastric arrhythmia: pathophysiology, clinical significance and future horizons.Clinical and experimental pharmacology & physiology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This study introduces high-resolution (HR) "entrainment mapping" for the analysis of gastric pacing and presents four demonstrations. Gastric pacing was initiated in a porcine model (typical amplitude 4 mA, pulse width 400 ms, period 17 s). Entrainment mapping was performed using flexible multielectrode arrays (</=192 electrodes; 92 cm(2)) and was analyzed using novel software methods. In the first demonstration, entrainment onset was quantified over successive waves in spatiotemporal detail. In the second demonstration, slow-wave velocity was accurately determined with HR field analysis, and paced propagation was found to be anisotropic (longitudinal 2.6 +/- 1.7 vs. circumferential 4.5 +/- 0.6 mm/s; P < 0.001). In the third demonstration, a dysrhythmic episode that occurred during pacing was mapped in HR, revealing an ectopic slow-wave focus and uncoupled propagations. In the fourth demonstration, differences were observed between paced and native slow-wave amplitudes (0.24 +/- 0.08 vs. 0.38 +/- 0.14 mV; P < 0.001), velocities (6.2 +/- 2.8 vs. 11.5 +/- 4.7 mm/s; P < 0.001), and activated areas (20.6 +/- 1.9 vs. 32.8 +/- 2.6 cm(2); P < 0.001). Entrainment mapping enables an accurate quantification of the effects of gastric pacing on slow-wave activity, offering an improved method to assess whether pacing protocols are likely to achieve physiologically and clinically useful outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.