ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2010
Differential protein abundance and function of UT-B urea transporters in human colon.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.Gut microbes · 2026Review
- Increased urea nitrogen salvaging by a remodeled gut microbiota helps nonhibernating pikas maintain protein homeostasis during winter.PLoS biology · 2025Article
- Energy-Dependent Urea Transports in Mammals and their Functional Consequences.Sub-cellular biochemistry · 2025Review
- Genes and Evolution of Urea Transporters.Sub-cellular biochemistry · 2025Review
- Tissue Distribution, Expression and Regulation of Urea Transporters.Sub-cellular biochemistry · 2025Review
- Physiological Functions of Urea Transporters.Sub-cellular biochemistry · 2025Review
- The role of rumen epithelial urea transport proteins in urea nitrogen salvage: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Physiological functions of urea transporter B.Pflugers Archiv : European journal of physiology · 2019Review
- Characterization of urea transport mechanisms in the intestinal tract of growing pigs.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Investigation of facilitative urea transporters in the human gastrointestinal tract.Physiological reports · 2018Article
- Generation and phenotypic analysis of mice lacking all urea transporters.Kidney international · 2017Article
- Hyperosmolality regulates UT-A6 urea transporter expression in the Caco-2 cell line.Physiological reports · 2016Article
- UT-B Urea Transporter Localization in the Bovine Gastrointestinal Tract.The Journal of membrane biology · 2016Article
- Glycosylation of solute carriers: mechanisms and functional consequences.Pflugers Archiv : European journal of physiology · 2016Review
- Urea transporter proteins as targets for small-molecule diuretics.Nature reviews. Nephrology · 2015Review
- The emerging physiological roles of the SLC14A family of urea transporters.British journal of pharmacology · 2011Review
- UT-B1 mediates transepithelial urea flux in the rat gastrointestinal tract.The Journal of membrane biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Facilitative UT-B urea transporters enable the passage of urea across cell membranes. Gastrointestinal urea transporters are thought to play a significant role in the urea nitrogen salvaging process that occurs between mammalian hosts and their gut bacteria. This study investigated the expression of UT-B urea transporters in different segments of human colon. Immunoblot analysis showed that human colon expressed a 35-kDa glycosylated UT-B protein in the colonic mucosa. The 35-kDa UT-B transporter was predominantly located in plasma membrane-enriched samples (P < 0.001; n = 6), and its expression was greater in the ascending colon compared with the descending colon (P < 0.01; n = 3). At the cellular level, UT-B transporters were located throughout colonocytes situated in the upper portion of the colonic crypts. Bidirectional trans-epithelial urea transport was significantly greater in the ascending colon than the descending colon (P < 0.05; n = 6). In addition, the facilitative urea transporter inhibitor 1,3,dimethylurea significantly reduced urea transport in the ascending colon (P < 0.05; n = 6) but had no effect in the descending colon (NS; n = 6). These results illustrate differential protein abundance of functional UT-B protein in different sections of the human colon, strongly correlating to regions that contain the largest populations of intestinal bacteria. This study suggests an important role for UT-B urea transporters in maintaining the symbiotic relationship between humans and their gut bacteria.
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