ArticleThe Journal of pharmacology and experimental therapeutics2010
Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve.
Article in The Journal of pharmacology and experimental therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Ocular Versus Oral Propranolol for Prevention and/or Treatment of Oxygen-Induced Retinopathy in a Rat Model.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2021Article
- Hollow Microcapsules as Periocular Drug Depot for Sustained Release of Anti-VEGF Protein.Pharmaceutics · 2019Article
- Characterization of liposomal carriers for the trans-scleral transport of Ranibizumab.Scientific reports · 2017Article
- A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics.Computer methods in biomechanics and biomedical engineering · 2016Article
- Topical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles.Translational vision science & technology · 2015Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- The effect of ocular pigmentation on transscleral delivery of triamcinolone acetonide.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2013Article
- Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery.Molecular pharmaceutics · 2013Article
- Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier.Pharmaceutical research · 2013Article
- Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.JAMA ophthalmology · 2013Article
- Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.PloS one · 2013Article
- Suprachoroidal delivery in a rabbit ex vivo eye model: influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes.Molecular vision · 2013Article
- Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: an in vitro model for the outer blood-retinal barrier.Molecular pharmaceutics · 2012Article
- RETRACTED: Influence of choroidal neovascularization and biodegradable polymeric particle size on transscleral sustained delivery of triamcinolone acetonide.International journal of pharmaceutics · 2012Article
- Intraocular distribution of melanin in human, monkey, rabbit, minipig and dog eyes.Experimental eye research · 2012Article
- Hydrophilic prodrug approach for reduced pigment binding and enhanced transscleral retinal delivery of celecoxib.Molecular pharmaceutics · 2012Article
- Brain mitochondrial drug delivery: influence of drug physicochemical properties.Pharmaceutical research · 2011Article
- Sclera-choroid-RPE transport of eight β-blockers in human, bovine, porcine, rabbit, and rat models.Investigative ophthalmology & visual science · 2011Article
- Influence of drug solubility and lipophilicity on transscleral retinal delivery of six corticosteroids.Drug metabolism and disposition: the biological fate of chemicals · 2011Article
- Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases.Drug delivery and translational research · 2011Article
Corrections and comments
- Retraction · 2014-12-26Concerns/Issues about Data · Concerns/Issues about Image · Falsification/Fabrication of Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · For more on author RS Kadam, see other RW posts: http://retractionwatch.com/?s=Rajendra+Kadam;
- Commented on by
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In vitro bovine eye tissue/phosphate-buffered saline, pH 7.4, partition coefficients (Kt:b), in vitro binding to natural melanin, and in vivo delivery at 1 h after posterior subconjunctival injection in Brown Norway rats were determined for eight beta-blockers. The Kt:b was in the order intact tissue, dry weight method >or= intact tissue, wet weight method corrected for tissue water and drug in tissue water >> intact tissue, wet weight method > homogenized tissue. In intact tissue methods, Kt:b followed the order choroid-retinal pigment epithelium (RPE) > trabecular meshwork > retina > sclera approximately optic nerve; propranolol > betaxolol > pindolol approximately timolol approximately metoprolol > sotalol approximately atenolol approximately nadolol. Intact tissue, wet weight log (Kt:b) correlated positively with log D for all tissues (R(2) of 0.7-0.9). Log (melanin binding capacity) correlated positively with choroid-RPE log (Kt:b) (R(2) of 0.5). With an increase in concentration, Kt:b decreased in trabecular meshwork for all beta-blockers and for some lipophilic beta-blockers in choroid-RPE and sclera. With an increase in drug lipophilicity, in vivo tissue distribution increased in choroid-RPE, iris-ciliary body, sclera, and cornea but exhibited a declining trend in retina, vitreous, and lens. In vitro bovine intact tissue, wet weight Kt:b correlated positively with rat in vivo tissue/vitreous humor distribution for sclera, choroid-RPE, and retina (R(2) of 0.985-0.993). In vitro tissue partition coefficients might be useful in predicting in vivo drug distribution after trans-scleral delivery. Less lipophilic solutes exhibiting limited nonproductive binding in choroid-RPE might exhibit greater trans-scleral delivery to the retina and vitreous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.