Trial reportThe European respiratory journal2010
Exercise stress echocardiography for the study of the pulmonary circulation.
Trial report in The European respiratory journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02965963 (The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Normal limits for the right ventricle-pulmonary circulation exercise echocardiography: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review.Arthritis research & therapy · 2016Pooled it
- Potential benefit of bosentan therapy in borderline or less severe pulmonary hypertension secondary to idiopathic pulmonary fibrosis-an interim analysis of results from a prospective, single-center, randomized, parallel-group study.BMC pulmonary medicine · 2017Trial
- Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension.Arthritis research & therapy · 2015Trial
- Trial
- Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR) as novel non-invasive parameter for elevated pulmonary vascular resistance in adults with unrepaired atrial septal defect.The international journal of cardiovascular imaging · 2026Article
- Chronic Thromboembolic Pulmonary Disease: Right Ventricular Function and Pulmonary Hemodynamics in a 4-Year Follow-Up.International journal of molecular sciences · 2025Article
- Right Heart Evaluation: A Tough Challenge for Clinicians.Life (Basel, Switzerland) · 2025Review
- How to Assess Pulmonary Circulation and Right Heart Chambers in Systemic Sclerosis Patients?Diagnostics (Basel, Switzerland) · 2025Review
- Biventricular responses to exercise and their relation to cardiorespiratory fitness in pediatric pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2024Article
- Simulation-Informed Power Budget Estimate of a Fully-Implantable Brain-Computer Interface.Annals of biomedical engineering · 2024Article
- Review
- Right ventricular functional recovery assessment with stress echocardiography and cardiopulmonary exercise testing after pulmonary embolism: a pilot prospective multicentre study.BMJ open respiratory research · 2023Article
- Assessment of pulmonary artery stiffness by multiparametric cardiac magnetic resonance-surrogate for right heart catheterization.Frontiers in cardiovascular medicine · 2023Article
- Exercise-Induced Pulmonary Hypertension Is Associated with High Cardiovascular Risk in Patients with HIV.Journal of clinical medicine · 2022Article
- Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET).Journal of clinical medicine · 2022Article
- Pulmonary vascular distensibility with passive leg raise is comparable to exercise and predictive of clinical outcomes in pulmonary hypertension.Pulmonary circulation · 2022Article
- Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort.Journal of the American College of Cardiology · 2020Article
- Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR): A Comparison Study between Ironman Athletes, Age Matched Controls and A General Community Cohort.Journal of clinical medicine · 2019Article
- A review of exercise pulmonary hypertension in systemic sclerosis.Journal of scleroderma and related disorders · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Exercise stress tests have been used for the diagnosis of pulmonary hypertension, but with variable protocols and uncertain limits of normal. The pulmonary haemodynamic response to progressively increased workload and recovery was investigated by Doppler echocardiography in 25 healthy volunteers aged 19-62 yrs (mean 36 yrs). Mean pulmonary artery pressure ((Ppa)) was estimated from the maximum velocity of tricuspid regurgitation. Cardiac output (Q) was calculated from the aortic velocity-time integral. Slopes and extrapolated pressure intercepts of (Ppa)-Q plots were calculated after using the adjustment of Poon for individual variability. A pulmonary vascular distensibility alpha was calculated from each (Ppa)-Q plot to estimate compliance. (Ppa) increased from 14+/-3 mmHg to 30+/-7 mmHg, and decreased to 19+/-4 mmHg after 5 min recovery. The slope of (Ppa)-Q was 1.37+/-0.65 mmHg x min(-1) x L(-1) with an extrapolated pressure intercept of 8.2+/-3.6 mmHg and an alpha of 0.017+/-0.018 mmHg(-1). These results agree with those of previous invasive studies. Multipoint (pa)-Q plots were well described by a linear approximation, from which resistance can be calulated. We conclude that exercise echocardiography of the pulmonary circulation is feasible and provides realistic resistance and compliance estimations. Measurements during recovery are unreliable because of rapid return to baseline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.