ReviewEpilepsy & behavior : E&B2010
Toward rational design of electrical stimulation strategies for epilepsy control.
Review in Epilepsy & behavior : E&B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Efficacy of tDCS in the Attenuation of Epileptic Paroxysmal Discharges and Clinical Seizures
NEED: Neuromed Epilepsy EEG Database. A Large Database of Electroencephalographic (EEG) Signals of Epilepsy Patients for Research Community.
Who cites it
24 citing papers in PubMed, 94 citations in OpenAlex.
- Experimental models of epilepsy: A comprehensive review of mechanisms, translational relevance, and future directions.Veterinary world · 2025Review
- Transcranial electrical stimulation (TES) in human motor Optimization: Mechanisms, safety, and emerging applications.Biochemistry and biophysics reports · 2025Review
- Effect of Deep Brain Stimulation in The Ventral Tegmental Area on Neuronal Activity in Local and Remote Brain Regions in Kindled Mice.Cell journal · 2023Article
- On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram.Frontiers in neuroinformatics · 2023Review
- Article
- Case Report: Prolonged Effects of Short-Term Transcranial Magnetic Stimulation on EEG Biomarkers, Spectral Power, and Seizure Frequency.Frontiers in neuroscience · 2022Article
- A Mixed Filtering Approach for Real-Time Seizure State Tracking Using Multi-Channel Electroencephalography Data.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- The Endocannabinoid System Activation as a Neural Network Desynchronizing Mediator for Seizure Suppression.Frontiers in behavioral neuroscience · 2020Review
- Antiepileptic Effects of a Novel Non-invasive Neuromodulation Treatment in a Subject With Early-Onset Epileptic Encephalopathy: Case Report With 20 Sessions of HD-tDCS Intervention.Frontiers in neuroscience · 2019Article
- Mesoscopic neuron population modeling of normal/epileptic brain dynamics.Cognitive neurodynamics · 2018Article
- Animal models of transcranial direct current stimulation: Methods and mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Review
- Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Experimental neurology · 2015Article
- Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm.Journal of computational neuroscience · 2014Article
- Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation.The Journal of physiology · 2013Article
- Inferring evoked brain connectivity through adaptive perturbation.Journal of computational neuroscience · 2013Article
- Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.Experimental neurology · 2013Article
- Controlling seizure-like events by perturbing ion concentration dynamics with periodic stimulation.PloS one · 2013Article
- Histocompatibility and in vivo signal throughput for PEDOT, PEDOP, P3MT, and polycarbazole electrodes.Journal of biomedical materials research. Part A · 2012Article
- The effects of acute responsive high frequency stimulation of the subiculum on the intra-hippocampal kainic acid seizure model in rats.Brain and behavior · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Electrical stimulation is emerging as a viable alternative for patients with epilepsy whose seizures are not alleviated by drugs or surgery. Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery. However, despite significant advances in our understanding of mechanisms of neural electrical stimulation, clinical electrotherapy for seizures relies heavily on empirical tuning of parameters and protocols. We highlight concurrent treatment goals with potentially conflicting design constraints that must be resolved when formulating rational strategies for epilepsy electrotherapy, namely, seizure reduction versus cognitive impairment, stimulation efficacy versus tissue safety, and mechanistic insight versus clinical pragmatism. First, treatment markers, objectives, and metrics relevant to electrical stimulation for epilepsy are discussed from a clinical perspective. Then the experimental perspective is presented, with the biophysical mechanisms and modalities of open-loop electrical stimulation, and the potential benefits of closed-loop control for epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.