Evidence map›Paper›PMID 19925624›Full record

SynthesisHeadache2010

MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.

Markus Schürks, Pamela M Rist, Tobias Kurth

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Headache, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Pooled it
  4. Migraine and mortality: a systematic review and meta-analysis.Cephalalgia : an international journal of headache · 2011
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Article
  10. The association between interatrial shunt and subtypes of migraine: a Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  11. Article
  12. Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025
    Review
  13. Review
  14. The Epigenetics of Migraine.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Exploring the Hereditary Nature of Migraine.Neuropsychiatric disease and treatment · 2021
    Review
  19. Advances in genetics of migraine.The journal of headache and pain · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Markus SchürksDivision of Preventive Medicine, Department of Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA.
Pamela M Rist
Tobias Kurth
General Department of Preventive Medicine · VNHarvard University · USSorbonne Université · FR

Funding

TRAINING PROGRAM IN EPIDEMIOLOGIC RESEARCH ON AGINGT32AG000158 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 1988 to 2015
$2.1M
NIA NIH HHS T32 AG000158
6 · The paper itself

Abstract

backgroundData on the association between the MTHFR 677C>T and ACE D/I polymorphisms and migraine including aura status are conflicting.

objectiveThe objective of this study is to perform a systematic review and meta-analysis on this topic.

methodsWe searched for studies published until March 2009 using electronic databases (MEDLINE, EMBASE, Science Citation Index) and reference lists of studies and reviews on the topic. Assessment for eligibility of studies and extraction of data was performed by 2 independent investigators. For each study we calculated the odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.

resultsThirteen studies investigated the association between the MTHFR 677C>T polymorphism and migraine. The TT genotype was associated with an increased risk for any migraine, which only appeared for migraine with aura (pooled OR = 1.48, 95% CI 1.02-2.13), but not for migraine without aura. Nine studies investigated the association of the ACE D/I polymorphism with migraine. The II genotype was associated with a reduced risk for migraine with aura (pooled OR = 0.71, 95% CI 0.55-0.93) and migraine without aura (pooled OR = 0.84, 95% CI 0.70-0.99). Results for both variants were driven by studies in non-Caucasian populations. Results among Caucasians did not suggest an association. Extractable data did not allow investigation of gene-gene interactions.

conclusionsThe MTHFR 677TT genotype is associated with an increased risk for migraine with aura, while the ACE II genotype is protective against both migraine with and without aura. Results for both variants appeared only among non-Caucasian populations. There was no association among Caucasians.

Indexed as

DNA Mutational AnalysisGenetic MarkersGenetic Predisposition to DiseaseGenetic TestingGenotypeHumansMethylenetetrahydrofolate Reductase (NADPH2)Migraine DisordersOdds RatioPeptidyl-Dipeptidase APolymorphism, GeneticRacial GroupsACE protein, humanGenetic MarkersMethylenetetrahydrofolate Reductase (NADPH2)Peptidyl-Dipeptidase A

Identifiers

PMID19925624
PMCPMC3071567
OpenAlexW2142290671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.