ReviewJournal of child psychology and psychiatry, and allied disciplines2010
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- A Systematic Review and a VigiBase Study of Accidental Clozapine Intoxications in Children and Adolescents.Human psychopharmacology · 2026Pooled it
- Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.The American journal of psychiatry · 2013Trial
- The hidden route: an exploratory study on autonomic influences in early phases of information processing.BMC psychology · 2025Article
- Septo-optic dysplasia associated with chromosome 15q13.3 duplication: a case report.Journal of Yeungnam medical science · 2023Article
- Maternal sleep quality during pregnancy is associated with neonatal auditory ERPs.Scientific reports · 2020Article
- The origin of NMDA receptor hypofunction in schizophrenia.Pharmacology & therapeutics · 2020Review
- Sleep Spindles and Auditory Sensory Gating: Two Measures of Cerebral Inhibition in Preschool-Aged Children are Strongly Correlated.Colorado journal of psychiatry & psychology · 2017Article
- Genetic knockout of the α7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner.Neuroscience letters · 2016Article
- Long-lasting changes in neural networks to compensate for altered nicotinic input.Biochemical pharmacology · 2015Review
- The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.Neuropharmacology · 2015Review
- Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation.Schizophrenia bulletin · 2015Review
- New Targets for Prevention of Schizophrenia: Is It Time for Interventions in the Premorbid Phase?Schizophrenia bulletin · 2015Article
- Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.Translational psychiatry · 2015Review
- The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.Brain, behavior, and immunity · 2015Article
- Prenatal choline and the development of schizophrenia.Shanghai archives of psychiatry · 2015Review
- Fetal programming of schizophrenia: select mechanisms.Neuroscience and biobehavioral reviews · 2015Review
- The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7.The Journal of biological chemistry · 2014Article
- Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.Molecular and cellular neurosciences · 2014Article
- Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.Brain, behavior, and immunity · 2014Article
- P50 sensory gating in infants.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between alpha7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.