ArticleJournal of neurotrauma2010
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
Article in Journal of neurotrauma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta-Analysis.Journal of neurotrauma · 2022Pooled it
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Neuroimaging Correlates of Functional Outcome Following Pediatric TBI.Advances in neurobiology · 2024Review
- White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury.Metabolites · 2023Article
- Neurometabolite alterations in traumatic brain injury and associations with chronic pain.Frontiers in neuroscience · 2023Article
- ILBInternational journal of molecular sciences · 2022Article
- The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group.Brain imaging and behavior · 2021Article
- Pathophysiology of Pediatric Traumatic Brain Injury.Frontiers in neurology · 2021Review
- Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma.Brain injury · 2019Article
- Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Magnetic resonance spectroscopy of fiber tracts in children with traumatic brain injury: A combined MRS - Diffusion MRI study.Human brain mapping · 2018Article
- Whole Brain Magnetic Resonance Spectroscopic Determinants of Functional Outcomes in Pediatric Moderate/Severe Traumatic Brain Injury.Journal of neurotrauma · 2018Article
- Proton Magnetic Resonance Spectroscopy (¹H-MRS) Study of Early Traumatic Brain Injury in Rabbits.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Diverging volumetric trajectories following pediatric traumatic brain injury.NeuroImage. Clinical · 2017Article
- The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time.Journal of neurotrauma · 2016Article
- Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury.Journal of neurotrauma · 2016Article
- Callosal Function in Pediatric Traumatic Brain Injury Linked to Disrupted White Matter Integrity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Functional neuroimaging of traumatic brain injury: advances and clinical utility.Neuropsychiatric disease and treatment · 2015Review
- Application of advanced neuroimaging modalities in pediatric traumatic brain injury.Journal of child neurology · 2014Review
- The new neurometabolic cascade of concussion.Neurosurgery · 2014Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (anterior and posterior), and their structural (diffusion tensor imaging; DTI) and neurobehavioral (neurocognitive functioning, bimanual coordination, and interhemispheric transfer time [IHTT]) correlates. Two groups of moderate/severe TBI patients (ages 12-18 years) were studied: post-acute (5 months post-injury; n = 10), and chronic (14.7 months post-injury; n = 8), in addition to 10 age-matched healthy controls. Creatine (energy metabolism) did not differ between groups across both ROIs and time points. In the TBI group, choline (membrane degeneration/inflammation) was elevated for both ROIs at the post-acute but not chronic period. N-acetyl aspartate (NAA) (neuronal/axonal integrity) was reduced initially for both ROIs, with partial normalization at the chronic time point. Posterior, not anterior, NAA was positively correlated with DTI fractional anisotropy (FA) (r = 0.88), and most domains of neurocognition (r range 0.22-0.65), and negatively correlated with IHTT (r = -0.89). Inverse corerlations were noted between creatine and posterior FA (r = -0.76), neurocognition (r range -0.22 to -0.71), and IHTT (r = 0.76). Multimodal studies at distinct time points in specific brain structures are necessary to delineate the course of the degenerative and reparative processes following TBI, which allows for preliminary hypotheses about the nature and course of the neural mechanisms of subsequent functional morbidity. This will help guide the future development of targeted therapeutic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.