ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
DeltaA mRNA and protein distribution in the zebrafish nervous system.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish.Frontiers in behavioral neuroscience · 2021Article
- Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis.Scientific reports · 2019Article
- Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.Scientific reports · 2017Article
- Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Physical interaction between the transmembrane proteins Delta and Notch allows only a subset of neural precursors to become neurons, as well as regulating other aspects of neural development. To examine the localization of Delta protein during neural development, we generated an antibody specific to zebrafish Delta A (Dla). Here, we describe for the first time the subcellular localization of Dla protein in distinct puncta at cell cortex and/or membrane, supporting the function of Dla in direct cell-cell communication. In situ RNA hybridization and immunohistochemistry revealed dynamic, coordinated expression patterns of dla mRNA and Dla protein in the developing and adult zebrafish nervous system. Dla expression is mostly excluded from differentiated neurons and is maintained in putative precursor cells at least until larval stages. In the adult brain, dla mRNA and Dla protein are expressed in proliferative zones normally associated with stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.