ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Downstream targets of GATA3 in the vestibular sensory organs of the inner ear.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- A single-nucleus transcriptomic atlas of human inner ear development.Nature neuroscience · 2026Article
- Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.Frontiers in molecular neuroscience · 2018Article
- Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.BMC molecular biology · 2017Article
- Gene expression profiling of the inner ear.Journal of anatomy · 2016Review
- Transactivation of human osteoprotegerin promoter by GATA-3.Scientific reports · 2015Article
- Hair cell generation by notch inhibition in the adult mammalian cristae.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Notch signaling in mammalian hair cell regeneration.Trends in developmental biology · 2013Article
- Article
- Probing the Xenopus laevis inner ear transcriptome for biological function.BMC genomics · 2012Article
- Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.PloS one · 2010Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Haploinsufficiency for the transcription factor GATA3 leads to hearing loss in humans. It is expressed throughout the auditory sensory epithelium (SE). In the vestibular organs, GATA3 is limited to the striola reversal zone of the utricle. Stereocilia orientation shifts 180 degrees at this region, which contains morphologically distinct type-I hair cells. The striola is conserved in all amniotes, its function is unknown, and GATA3 is the only known marker of the reversal zone. To identify downstream targets of GATA3 that might point to striolar function, we measured gene expression differences between striolar and extra-striolar SE. These were compared with profiles after GATA3 RNAi and GATA3 over-expression. We identified four genes (BMP2, FKHL18, LMO4, and MBNL2) that consistently varied with GATA3. Two of these (LMO4 and MBNL2) were shown to be direct targets of GATA3 by ChIP. Our results suggest that GATA3 impacts WNT signaling in this region of the sensory macula.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.