ArticleGenetic epidemiology2009
Detecting gene-environment interactions in genome-wide association data.
Article in Genetic epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits inAnimals : an open access journal from MDPI · 2020Article
- Effect of population stratification on SNP-by-environment interaction.Genetic epidemiology · 2019Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
- A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions.Current hypertension reports · 2017Review
- Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population.Journal of geriatric cardiology : JGC · 2016Article
- Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention.The Yale journal of biology and medicine · 2015Review
- The differential view of genotype-phenotype relationships.Frontiers in genetics · 2015Article
- Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.Human genetics · 2012Review
- Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.Carcinogenesis · 2012Article
- Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2.BMC bioinformatics · 2012Article
- Genetics of nonsyndromic orofacial clefts.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2012Review
- An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back.Research in human development · 2011Article
- Gene-environment interaction in psychological traits and disorders.Annual review of clinical psychology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Despite the importance of gene-environment (GxE) interactions in the etiology of common diseases, little work has been done to develop methods for detecting these types of interactions in genome-wide association study data. This was the focus of Genetic Analysis Workshop 16 Group 10 contributions, which introduced a variety of new methods for the detection of GxE interactions in both case-control and family-based data using both cross-sectional and longitudinal study designs. Many of these contributions detected significant GxE interactions. Although these interactions have not yet been confirmed, the results suggest the importance of testing for interactions. Issues of sample size, quantifying the environmental exposure, longitudinal data analysis, family-based analysis, selection of the most powerful analysis method, population stratification, and computational expense with respect to testing GxE interactions are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.