ArticleMedical oncology (Northwood, London, England)2010
Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression.
Article in Medical oncology (Northwood, London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Identification and validation of biomarkers in gastric cancer-associated membranous nephropathy: Insights from comprehensive bioinformatics analysis and machine learning.Frontiers in immunology · 2025Article
- BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation.Scientific reports · 2022Article
- Detection of circulating BMP5 as a risk factor for Barrett's esophagus.Scientific reports · 2020Article
- CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target.Cancer communications (London, England) · 2020Review
- BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway.Aging · 2017Article
- NF-κB Signaling in Gastric Cancer.Toxins · 2017Review
- Article
- Utilizing BMP-2 muteins for treatment of multiple myeloma.PloS one · 2017Article
- Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.BioMed research international · 2017Article
- Expression of bone morphogenetic protein-2 and -7 in urinary bladder cancer predicts time to tumor recurrence.Archives of medical science : AMS · 2015Article
- Regulation of cellular iron metabolism and its implications in lung cancer progression.Medical oncology (Northwood, London, England) · 2014Review
- Increased hepcidin expression in non-small cell lung cancer tissue and serum is associated with clinical stage.Thoracic cancer · 2014Article
- Imbalanced expression of Tif1γ inhibits pancreatic ductal epithelial cell growth.American journal of cancer research · 2014Article
- Article
- Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin.Molecular cancer · 2013Article
- Cancer stem cells: the 'heartbeat' of gastric cancer.Journal of gastroenterology · 2013Review
- Gastric stem cells and gastric cancer stem cells.Anatomy & cell biology · 2013Article
- Identification of a 5-gene signature for clinical and prognostic prediction in gastric cancer patients upon microarray data.Medical oncology (Northwood, London, England) · 2013Article
- Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines.PloS one · 2013Article
- The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic protein-2 (BMP-2) was reported to enhance migration, invasion, and metastasis at the various types of cancer cells. The purpose of this study is to identify the role of BMP-2 in progression of gastric cancer. Forty-four patients with operable gastric cancer were enrolled. Also, twenty healthy volunteers were enrolled as control group. All patients received gastrectomy with D2 lymphadenectomy, and surgical staging was performed. Whole blood was obtained preoperatively in all patients, and serum BMP-2 levels were quantified by commercially available ELISA kit. Immunohistochemical stain for BMP-2 in all gastric cancer tissues was performed using tissue microarray. All patients showed increased serum BMP-2 levels compared with control group, when upper normal limit was defined as the mean of control serum level+2×standard deviation. The mean serum BMP-2 level of lymph node positive group was significantly elevated than that of lymph node-negative group (382.7 pg/ml, 95% CI 341.99-423.4 pg/ml vs 211.69 pg/ml, 95% CI 191.09-232.29 pg/ml, P<0.001). The serum BMP-2 was strongly correlated with the depth of invasion (T stage) and the extent of regional lymph node involvement (N stage) (r=0.662, P<0.001 and r=0.831, P<0.001, respectively). Moreover, the serum BMP-2 was correlated with the grade of tumor histology(r=0.421, P=0.008). Immunohistochemical stain showed the specific expression of BMP-2 in cancer cells compared with normal gastric mucosa. In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally advanced gastric cancer.
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