ReviewClinical rheumatology2010
Is osteoarthritis a heterogeneous disease that can be stratified into subsets?
Review in Clinical rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature.BMC musculoskeletal disorders · 2016Pooled it
- Trial
- A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021Trial
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- Cryogel-based therapeutic platforms for disease modification in osteoarthritis.npj biomedical innovations · 2026Review
- Exosomes from mesenchymal stem/stromal cells and their therapeutic role in osteoarthritic pain.Journal of experimental orthopaedics · 2026Article
- Analysis of serum biomarker profiles in DDH Hip osteoarthritis versus primary hip osteoarthritis: a prospective observational study in a recent arthroplasty cohort.Journal of orthopaedic surgery and research · 2026Observational
- Multifaceted imaging strategies for clinical trials of knee osteoarthritis-a tightly interlinked value and precision chain.Skeletal radiology · 2025Review
- Long-Acting Extracellular Vesicle-Based Biologics in Osteoarthritis Immunotherapy.Bioengineering (Basel, Switzerland) · 2025Review
- Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes.Frontiers in medicine · 2025Article
- "You don't put it down to arthritis": A qualitative study of the first symptoms recalled by individuals with knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- Article
- Mesenchymal progenitor cells from non-inflamed versus inflamed synovium post-ACL injury present with distinct phenotypes and cartilage regeneration capacity.Stem cell research & therapy · 2023Article
- Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort.PloS one · 2023Article
- Early pain in females is linked to late pathological features in murine experimental osteoarthritis.PeerJ · 2023Article
- Correlations between metabolites in the synovial fluid and serum: A mouse injury study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Article
- Multi-omics molecular biomarkers and database of osteoarthritis.Database : the journal of biological databases and curation · 2022Article
- Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs.Trends in pharmacological sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is a heterogeneous disease characterized by variable clinical features, biochemical/genetic characteristics, and responses to treatments. To optimize palliative effects of current treatments and develop efficacious disease-modifying interventions, treatments may need to be tailored to the individual or a subset of osteoarthritic joints. The purpose of this review is to explore the current literature on the clinical and physiological variability in osteoarthritis and potential for stratifying patients. Several stratifications have been reported, including mechanism of onset, stage of disease progression, involved joints, inflammatory levels, and effusion. Most of these methods revealed two to three unique subsets of osteoarthritis. Osteoarthritic joints may be stratified by an array of variables, some transient and others consistent throughout the disease process. Future research needs to continue to explore stratification techniques since these may be the key to optimizing palliative interventions and developing disease-modifying interventions for subsets within this heterogeneous disease.
Indexed as
Identifiers
19924499What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.