ArticleInternational journal of legal medicine2010
Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.
Article in International journal of legal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Immunohistological detection of pentosidine in the epiglottis:A contribution to molecular age estimation.International journal of legal medicine · 2026Article
- Structure and Function of the Extracellular Matrix in Normal and Pathological Conditions: Looking at the Bicuspid Aortic Valve.International journal of molecular sciences · 2025Review
- Molecular age estimation based on posttranslational protein modifications in bone: why the type of bone matters.International journal of legal medicine · 2023Article
- Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method.ACS omega · 2020Article
- Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.International journal of legal medicine · 2020Article
- Molecular Processes Implicated in Human Age-Related Nuclear Cataract.Investigative ophthalmology & visual science · 2019Review
- Old Proteins in Man: A Field in its Infancy.Trends in biochemical sciences · 2016Review
- Age estimation based on aspartic acid racemization in human sclera.International journal of legal medicine · 2016Article
- Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.International journal of legal medicine · 2014Article
- Age determination of adult individuals by three-dimensional modelling of canines.International journal of legal medicine · 2014Article
- Age estimation based on a combined arteriosclerotic index.International journal of legal medicine · 2012Article
- Age and gender-dependent bone density changes of the human skull disclosed by high-resolution flat-panel computed tomography.International journal of legal medicine · 2011Article
- Heart rate: a forgotten link in coronary artery disease?Nature reviews. Cardiology · 2011Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspartic acid racemisation (AAR) results in an age-dependent accumulation of D: -aspartic acid in durable human proteins and can be used as a basis for age estimation. Routinely, age estimation based on AAR is performed by analysis of dentine. However, in forensic practise, teeth are not always available. Non-dental tissues for age estimation may be suitable for age estimation based on AAR if they contain durable proteins that can be purified and analysed. Elastin is such a durable protein. To clarify if purified elastin from arteries is a suitable sample for biochemical age estimation, AAR was determined in purified elastin from arteries from individuals of known age (n = 68 individuals, including n = 15 putrefied corpses), considering the influence of different stages of atherosclerosis and putrefaction on the AAR values. AAR was found to increase with age. The relationship between AAR and age was good enough to serve as basis for age estimation, but worse than known from dentinal proteins. Intravital and post-mortem degradation of elastin may have a moderate effect on the AAR values. Age estimation based on AAR in purified elastin from arteries may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g., no available teeth and body parts).
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