ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2010
Photoreceptor responses of fruitflies with normal and reduced arrestin content studied by simultaneous measurements of visual pigment fluorescence and ERG.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The Role of Reversible Phosphorylation ofInternational journal of molecular sciences · 2022Review
- Autofluorescent Biomolecules in Diptera: From Structure to Metabolism and Behavior.Molecules (Basel, Switzerland) · 2022Review
- Functional interplay of visual, sensitizing and screening pigments in the eyes of Drosophila and other red-eyed dipteran flies.The Journal of physiology · 2017Review
- Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.Scientific reports · 2015Article
- Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster.Scientific reports · 2015Article
- A model for non-monotonic intensity coding.Royal Society open science · 2015Article
- Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ectoplasm, ghost in the R cell machine?Developmental neurobiology · 2011Review
- Metarhodopsin control by arrestin, light-filtering screening pigments, and visual pigment turnover in invertebrate microvillar photoreceptors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- On visual pigment templates and the spectral shape of invertebrate rhodopsins and metarhodopsins.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have simultaneously measured the electroretinogram (ERG) and the metarhodopsin content via fluorescence in white-eyed, wild-type Drosophila and the arrestin2 hypomorphic mutant (w(-);arr2 (3)) at a range of stimulus wavelengths and intensities. Photoreceptor response amplitude and termination (transition between full repolarization and prolonged depolarizing afterpotential, PDA) were related to visual pigment conversions and arrestin concentration. The data were implemented in a kinetic model of the rhodopsin-arrestin cycle, allowing us to estimate the active metarhodopsin concentration as a function of effective light intensity and arrestin concentration. Arrestin reduction in the mutant modestly increased the light sensitivity and decreased the photoreceptor dynamic range. Compared to the wild type, in the mutant the transition between full repolarization and PDA occurred at a lower metarhodopsin fraction and was more abrupt. We developed a steady-state stochastic model to interpret the dependence of the PDA on effective light intensity and arrestin content and to help deduce the arrestin to rhodopsin ratio from the sensitivity and PDA data. The feasibility of different experimental methods for the estimation of arrestin content from ERG and PDA is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.