ArticlePsychopharmacology2010
Cortical activation during cocaine use and extinction in rhesus monkeys.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Expert appraisal of criteria for nonhuman primate substance use disorder models: An international Delphi study.General psychiatry · 2026Article
- Empirical mode decomposition of local field potential data from optogenetic experiments.Frontiers in computational neuroscience · 2023Article
- Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice.PloS one · 2019Article
- Utility of Nonhuman Primates in Substance Use Disorders Research.ILAR journal · 2017Review
- Chronic cocaine disrupts mesocortical learning mechanisms.Brain research · 2015Review
- Methylenedioxypyrovalerone (MDPV) mimics cocaine in its physiological and behavioral effects but induces distinct changes in NAc glucose.Frontiers in neuroscience · 2015Article
- Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine.Frontiers in neuroscience · 2015Article
- PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.Neuropharmacology · 2014Review
- Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging.Neuropharmacology · 2014Review
- Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.Advances in pharmacology (San Diego, Calif.) · 2014Review
- Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates.Current opinion in neurobiology · 2013Article
- Optogenetically evoked gamma oscillations are disturbed by cocaine administration.Frontiers in cellular neuroscience · 2013Article
- Nonhuman primate models of social behavior and cocaine abuse.Psychopharmacology · 2012Review
- Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation.Current topics in behavioral neurosciences · 2012Article
- Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.Nature reviews. Neuroscience · 2011Review
- Neuroimaging and drug taking in primates.Psychopharmacology · 2011Review
- Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration.Neuroscience letters · 2011Article
- fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Nonhuman primate positron emission tomography neuroimaging in drug abuse research.The Journal of pharmacology and experimental therapeutics · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAcute re-exposure to cocaine or drug cues associated with cocaine use can elicit drug craving and relapse. Neuroimaging studies have begun to define neurobiological substrates underlying the acute effects of cocaine or cocaine cues in cocaine-dependent subjects.
objectiveThe present study was the first to use functional brain imaging to document acute cocaine-induced changes in brain activity during active drug use in nonhuman primates. MATERIALS AND
methodsPositron emission tomography imaging with O15-labeled water was used to measure drug-induced changes in cerebral blood flow. The acute effects of cocaine administered noncontingently were characterized in four drug-naïve rhesus monkeys. The same subjects were trained to self-administer cocaine under a fixed ratio schedule during image acquisition. Subsequently, three subjects with an extensive history of cocaine use were trained to self-administer cocaine under a second-order schedule. The same subjects also underwent extinction sessions during which saline was substituted for cocaine under the second-order schedule.
resultsNoncontingent administration of cocaine in drug-naïve subjects induced robust activation of prefrontal cortex localized primarily to the dorsolateral regions. In contrast, the pattern of brain activation induced by self-administered cocaine differed qualitatively and included anterior cingulate cortex. Moreover, drug-associated stimuli during extinction also induced robust activation of prefrontal cortex.
conclusionsThe effects of cocaine and associated cues extend beyond the limbic system to engage brain areas involved in cognitive processes. The identification of neural circuits underlying the direct pharmacological and conditioned stimulus effects of cocaine may be highly relevant toward efforts to develop treatments for cocaine addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.