Detection of microbial DNAemia: does it matter for sepsis management?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed.

1. Impact of multiplex PCR on antimicrobial treatment in febrile neutropenia: a randomized controlled study.Medical microbiology and immunology · 2015
   Trial
2. Blood Bacteria-Free DNA in Septic Mice Enhances LPS-Induced Inflammation in Mice through Macrophage Response.International journal of molecular sciences · 2022
   Article
3. Control of Infectious Diseases in the Era of European Clinical Microbiology Laboratory Consolidation: New Challenges and Opportunities for the Patient and for Public Health Surveillance.Frontiers in medicine · 2018
   Article
4. Mortality, intensive care treatment, and cost evaluation: Role of a polymerase chain reaction assay in patients with sepsis.The Journal of international medical research · 2018
   Article
5. The intestinal microbiome and surgical disease.Current problems in surgery · 2016
   Review
6. The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.Shock (Augusta, Ga.) · 2016
   Review
7. Metagenomic analysis of bloodstream infections in patients with acute leukemia and therapy-induced neutropenia.Scientific reports · 2016
   Article
8. Enhanced diagnostic yields of bacteremia and candidemia in blood specimens by PCR-electrospray ionization mass spectrometry.Journal of clinical microbiology · 2013
   Article
9. Assessment of a semi-automated protocol for multiplex analysis of sepsis-causing bacteria with spiked whole blood samples.MicrobiologyOpen · 2013
   Article
10. Rapid diagnosis of bloodstream infections with PCR followed by mass spectrometry.PloS one · 2013
    Article
11. Rapid detection of bloodstream pathogens by real-time PCR in patients with sepsis.Wiener klinische Wochenschrift · 2012
    Article
12. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.Annals of surgery · 2012
    Article
13. Advances and prospects for molecular diagnostics of fungal infections.Current infectious disease reports · 2010
    Article
14. Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia.Journal of clinical microbiology · 2010
    Article
15. Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials.Critical care (London, England) · 2010
    Article

Corrections and comments

• Comment on
  A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis.2010

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as