ArticlePloS one2009
Three distinct domains contribute to nuclear transport of murine Foxp3.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis.European journal of medical research · 2023Review
- Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Structure-Guided Delineation of FOXP3 Regulation Mechanism in IPEX.Advances in experimental medicine and biology · 2021Article
- FoxP3 in TClinical and experimental immunology · 2020Review
- Foxp3 Post-translational Modifications and Treg Suppressive Activity.Frontiers in immunology · 2019Review
- FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The regulation of immune tolerance by FOXP3.Nature reviews. Immunology · 2017Review
- Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.The Journal of biological chemistry · 2015Article
- The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.PLoS genetics · 2015Article
- Genome-wide analysis of cancer cell-derived Foxp3 target genes in human tongue squamous cell carcinoma cells.International journal of oncology · 2015Article
- Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling.PloS one · 2015Article
- Molecular cloning and analysis of gonadal expression of Foxl2 in the rice-field eel Monopterus albus.Scientific reports · 2014Article
- Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases.Journal of genetics · 2013Review
- Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.Experimental and molecular pathology · 2012Review
- Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells.Genes and immunity · 2012Review
- Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.Immunology and cell biology · 2012Review
- Article
- First insight into the kinome of human regulatory T cells.PloS one · 2012Article
- Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.Current opinion in immunology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Foxp3, a 47-kDa transcription factor, is necessary for the function of CD4+CD25+ regulatory T cells (Tregs), with an essential role in the control of self-reactive T cells and in preventing autoimmunity. Activation of Tregs by TCR engagement results in upregulation of Foxp3 expression, followed by its rapid nuclear transport and binding to chromatin. Here, we identify three distinct Foxp3 domains that contribute to nuclear transport. The first domain (Domain 1) comprises the C-terminal 12 amino acids. The second domain (Domain 2) is located immediately N-terminal to the forkhead domain (FHD), recently reported to be a binding site for the runt-related transcription factor 1/acute myeloid leukemia 1 (Runx1/AML1). The third domain (Domain 3) is located within the N-terminal first 51 amino acids. Unlike the known nuclear localization signals (NLSs), none of these three regions are rich in basic residues and do not bear any similarity to known monopartite or bipartite NLSs that have one or more clusters of basic amino acids. The basic arginine-lysine-lysine-arginine (RKKR) sequence, located 12-aa from the C-terminal end of Foxp3 was previously reported to be a nuclear localization signal (NLS) for several proteins, including for a GFP-Foxp3 hybrid. Evidence is provided here that in the full-length native Foxp3 RKKR does not function as an NLS. The data reported in this study indicates that Foxp3 achieves nuclear transport by binding to other nuclear factors and co-transporting with them to the nucleus.
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Registered trials
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