ArticlePLoS biology2009
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 114 citations in OpenAlex.
- Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia.Biomolecules · 2026Article
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.Frontiers in bioscience (Landmark edition) · 2024Article
- Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fastediScience · 2024Article
- Nonlinear DNA methylation trajectories in aging male mice.Nature communications · 2024Article
- Epigenetics as a link between environmental factors and dementia risk.Journal of Alzheimer's disease reports · 2024Review
- The role of nutrition and oxidative stress as aging factors inJournal of clinical biochemistry and nutrition · 2023Article
- Mitophagy-promoting agents and their ability to promote healthy-aging.Biochemical Society transactions · 2023Article
- Genomic Instability and Epigenetic Changes during Aging.International journal of molecular sciences · 2023Review
- Structure, Function, and Molecular Landscapes of the Aging Retina.Annual review of vision science · 2023Review
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction.PloS one · 2023Article
- Role of primary aging hallmarks in Alzheimer´s disease.Theranostics · 2023Review
- Gene co-expression analyses of health(span) across multiple species.NAR genomics and bioinformatics · 2022Article
- CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Axenic Culture ofInternational journal of molecular sciences · 2022Article
- Hsp90: From Cellular to Organismal Proteostasis.Cells · 2022Review
- Pleiotropic effects of mitochondria in aging.Nature aging · 2022Review
- Biological age and environmental risk factors for dementia and stroke: Molecular mechanisms.Frontiers in aging neuroscience · 2022Review
- The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response inFrontiers in aging · 2022Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
How dietary restriction (DR) increases lifespan and decreases disease burden are questions of major interest in biomedical research. Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan across five strains of mice, and expression of these genes decreases with age and diabetes in mice. Furthermore, in Caenorhabditis elegans, cbp-1 is induced by bacterial dilution DR (bDR) and the daf-2 mutation, and cbp-1 RNAi specifically in adults completely blocks lifespan extension by three distinct protocols of DR, partially blocks lifespan extension by the daf-2 mutation but not of cold, and blocks delay of other age-related pathologies by bDR. Inhibiting the C. elegans ortholog of SATB-1 and CBP-binding partners daf-16 and hsf-1 also attenuates lifespan extension by bDR, but not other protocols of DR. In a transgenic Abeta42 model of Alzheimer's disease, cbp-1 RNAi prevents protective effects of bDR and accelerates Abeta42-related pathology. Furthermore, consistent with the function of CBP as a histone acetyltransferase, drugs that enhance histone acetylation increase lifespan and reduce Abeta42-related pathology, protective effects completely blocked by cbp-1 RNAi. Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.