ArticlePloS one2009
Transcriptome profiling of human pre-implantation development.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07076719 (Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.Human reproduction updatePooled it
- Transcriptomic Analysis Reveals Multilayer Regulation Underlying Development and Pregnancy in the Malayan Pangolin.Animal genetics · 2026Article
- In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis.Nature protocols · 2024Review
- A review on trends in development and translation of omics signatures in cancer.Computational and structural biotechnology journal · 2024Review
- Species Choice and Model Use: Reviving Research on Human Development.Journal of the history of biology · 2024Article
- Interaction network of human early embryonic transcription factors.EMBO reports · 2024Article
- Sexual Orientation in Twins: Evidence That Human Sexual Identity May Be Determined Five Days Following Fertilization.Cureus · 2023Review
- R-loop landscape in mature human sperm: Regulatory and evolutionary implications.Frontiers in genetics · 2023Article
- Review
- Oocyte maturation abnormalities - A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility pheneomina.Turkish journal of obstetrics and gynecology · 2022Article
- The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.Human reproduction (Oxford, England) · 2021Article
- Current Advancements in Noninvasive Profiling of the Embryo Culture Media Secretome.International journal of molecular sciences · 2021Review
- Small Noncoding RNA Signatures for Determining the Developmental Potential of an Embryo at the Morula Stage.International journal of molecular sciences · 2020Article
- Overlooked roles of DNA damage and maternal age in generating human germline mutations.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mechanisms of gene regulation in human embryos and pluripotent stem cells.Development (Cambridge, England) · 2017Review
- Global gene expression profiling and senescence biomarker analysis of hESC exposed to HStem cell research & therapy · 2017Article
- Exploratory bioinformatics investigation reveals importance of "junk" DNA in early embryo development.BMC genomics · 2017Article
- Vertebrate Embryonic Cleavage Pattern Determination.Advances in experimental medicine and biology · 2017Review
- Exploring timing activation of functional pathway based on differential co-expression analysis in preimplantation embryogenesis.Oncotarget · 2016Article
- The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes.Cell reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known. METHODOLOGY: By applying microarray on 397 human oocytes and embryos at six developmental stages, we studied the transcription dynamics during human preimplantation development. PRINCIPAL
findingsWe found that the preimplantation development consisted of two main transitions: from metaphase-II oocyte to 4-cell embryo where mainly the maternal genes were expressed, and from 8-cell embryo to blastocyst with down-regulation of the maternal genes and up-regulation of embryonic genes. Human preimplantation development proved relatively autonomous. Genes predominantly expressed in oocytes and embryos are well conserved during evolution. SIGNIFICANCE: Our database and findings provide fundamental resources for understanding
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