ArticleProteomics. Clinical applications2009
Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain.
Article in Proteomics. Clinical applications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- The Neuropathology of Alcohol Use Disorder: Cellular Insights From Human Post-Mortem Studies.Journal of neurochemistry · 2025Review
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- Inter-Regional Proteomic Profiling of the Human Brain Using an Optimized Protein Extraction Method from Formalin-Fixed Tissue to Identify Signaling Pathways.International journal of molecular sciences · 2023Article
- Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines.Addiction biology · 2016Article
- Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes.Molecular brain · 2014Article
- Proteomic approaches and identification of novel therapeutic targets for alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Alcohol-related brain damage in humans.PloS one · 2014Article
- Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence.BMC genomics · 2013Article
- Prenatal alcohol exposure alters the cerebral cortex proteome in weanling rats.Reproductive toxicology (Elmsford, N.Y.) · 2013Article
- Article
- Proteogenomics of synaptosomal mitochondrial oxidative stress.Free radical biology & medicine · 2012Article
- Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics.Frontiers in genetics · 2012Article
- Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain.Pharmacology, biochemistry, and behavior · 2011Article
- Clinical and pathological features of alcohol-related brain damage.Nature reviews. Neurology · 2011Review
- Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.Translational psychiatry · 2011Article
- Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus.Current neuropharmacology · 2011Article
- Understanding the Global Problem of Drug Addiction is a Challenge for IDARS Scientists.Current neuropharmacology · 2011Article
- Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.Progress in molecular biology and translational science · 2011Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes which alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post-mortem human brain of six chronic alcoholics and six non-alcoholic controls were compared using 2D-DIGE. Functionally affected and spared regions (superior frontal gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty-nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the OC with an overlap of 23 proteins. Additionally, the SFG was compared to the OC within each group (alcoholics or controls) to identify region specific differences. A selection were identified by MALDI-TOF mass spectrometry revealing proteins involved in vesicle transport, metabolism, folding and trafficking, and signal transduction, all of which have the potential to influence synaptic activity. A number of proteins identified in this study have been previously related to alcoholism; however, the focus on synaptic proteins has also uncovered novel alcoholism-affected proteins. Further exploration of these proteins will illuminate the mechanisms altering synaptic plasticity, and thus neuronal signaling and response, in the alcoholic brain.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.