ArticlePloS one2009
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels.Nature metabolism · 2023Article
- High Dietary Fat Consumption Impairs Axonal Mitochondrial FunctionThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mechanisms for the maintenance and regulation of axonal energy supply.Journal of neuroscience research · 2019Review
- Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria.Cell reports · 2019Article
- Review
- Analysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kinetics.Biology open · 2017Article
- Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.PLoS genetics · 2016Article
- MitoLoc: A method for the simultaneous quantification of mitochondrial network morphology and membrane potential in single cells.Mitochondrion · 2015Article
- Article
- A mitochondrial basis for Huntington's disease: therapeutic prospects.Molecular and cellular biochemistry · 2014Review
- The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit.The Journal of cell biology · 2013Article
- The dynamics of the mitochondrial organelle as a potential therapeutic target.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle.Journal of vascular research · 2013Review
- The axonal transport of mitochondria.Journal of cell science · 2012Review
- Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action.Human molecular genetics · 2011Article
- Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol γ.Nucleic acids research · 2011Review
- Animal models of mitochondrial DNA transactions in disease and ageing.Experimental gerontology · 2010Review
- Review
- Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations in mitochondrial DNA polymerase (pol gamma) cause several progressive human diseases including Parkinson's disease, Alper's syndrome, and progressive external ophthalmoplegia. At the cellular level, disruption of pol gamma leads to depletion of mtDNA, disrupts the mitochondrial respiratory chain, and increases susceptibility to oxidative stress. Although recent studies have intensified focus on the role of mtDNA in neuronal diseases, the changes that take place in mitochondrial biogenesis and mitochondrial axonal transport when mtDNA replication is disrupted are unknown. Using high-speed confocal microscopy, electron microscopy and biochemical approaches, we report that mutations in pol gamma deplete mtDNA levels and lead to an increase in mitochondrial density in Drosophila proximal nerves and muscles, without a noticeable increase in mitochondrial fragmentation. Furthermore, there is a rise in flux of bidirectional mitochondrial axonal transport, albeit with slower kinesin-based anterograde transport. In contrast, flux of synaptic vesicle precursors was modestly decreased in pol gamma-alpha mutants. Our data indicate that disruption of mtDNA replication does not hinder mitochondrial biogenesis, increases mitochondrial axonal transport, and raises the question of whether high levels of circulating mtDNA-deficient mitochondria are beneficial or deleterious in mtDNA diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.