Evidence map›Paper›PMID 19924131›Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2010

Maternal-fetal and neonatal pharmacogenomics: a review of current literature.

Y J Blumenfeld, M F Reynolds-May, R B Altman, Y Y El-Sayed

Abstract readReview
In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Y J BlumenfeldDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA. yairb@stanford.edu
M F Reynolds-May
R B Altman
Y Y El-Sayed
Stanford University · USStanford Medicine · USYale University · US

Funding

THE STANFORD PHARMACOGENETICS KNOWLEDGE BASEU01GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2000 to 2009
$24.0M
NIGMS NIH HHS U01 GM061374
6 · The paper itself

Abstract

Pharmacogenomics, the study of specific genetic variations and their effect on drug response, will likely give rise to many applications in maternal-fetal and neonatal medicine; yet, an understanding of these applications in the field of obstetrics and gynecology and neonatal pediatrics is not widespread. This review describes the underpinnings of the field of pharmacogenomics and summarizes the current pharmacogenomic inquiries in relation to maternal-fetal medicine-including studies on various fetal and neonatal genetic cytochrome P450 (CYP) enzyme variants and their role in drug toxicities (for example, codeine metabolism, sepsis and selective serotonin reuptake inhibitor (SSRI) toxicity). Potential future directions, including alternative drug classification, improvements in drug efficacy and non-invasive pharmacogenomic testing, will also be explored.

Indexed as

PharmacogeneticsPolymorphism, GeneticAnalgesics, OpioidCytochrome P-450 Enzyme SystemDrug-Related Side Effects and Adverse ReactionsFemaleFetal DevelopmentHumansInactivation, MetabolicInfant, NewbornSelective Serotonin Reuptake InhibitorsSepsisTeratogensAnalgesics, OpioidCytochrome P-450 Enzyme SystemSelective Serotonin Reuptake InhibitorsTeratogens

Identifiers

PMID19924131
PMCPMC3098749
OpenAlexW2060705686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.