ReviewCurrent opinion in hematology2010
Neutrophil microdomains: linking heterocellular interactions with vascular injury.
Review in Current opinion in hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Ultrasound-driven mechanical immunomodulation enhances tumor treatment sensitivity: advances from tumor mechanical immunobiology to immunotherapy applications.Frontiers in immunology · 2026Review
- Therapeutic hypothermia attenuates physiologic, histologic, and metabolomic markers of injury in a porcine model of acute respiratory distress syndrome.Physiological reports · 2022Article
- Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion.Frontiers in chemistry · 2019Article
- Pulmonary endothelial activation caused by extracellular histones contributes to neutrophil activation in acute respiratory distress syndrome.Respiratory research · 2016Article
- Regulation of leucocyte homeostasis in the circulation.Cardiovascular research · 2015Review
- Platelet-rich plasma extract prevents pulmonary edema through angiopoietin-Tie2 signaling.American journal of respiratory cell and molecular biology · 2015Article
- Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.Clinics in chest medicine · 2014Review
- Endothelium-neutrophil interactions in ANCA-associated diseases.Journal of the American Society of Nephrology : JASN · 2012Review
- Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.Free radical biology & medicine · 2012Review
- The acute respiratory distress syndrome: pathogenesis and treatment.Annual review of pathology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewNeutrophil infiltration is an important feature in inflammatory scenarios. Before these cells infiltrate tissues, however, they contribute to crucial intravascular events in which neutrophil microdomains mediate heterotypic interactions with endothelial cells, red blood cells and/or platelets. In vascular diseases, this can result in exacerbated neutrophil activation, subsequent vascular injury and obstruction of microcirculatory blood flow. This review discusses recent advances in elucidating these neutrophil domains and their associated functions in cell adhesion. RECENT
findingsNeutrophil recruitment is mediated by sequential interactions with the endothelium, termed rolling, adhesion and extravasation. Evidence points to novel signaling pathways induced during the rolling phase resulting in the transition to leukocyte adhesion, which appear to contribute to chemokine mediated activation. In addition, specific neutrophil microdomains are important for interactions with other hematopoietic cells inducing reductions in microvascular flow and injury. SUMMARY: Neutrophils integrate signals received from the endothelium to act as linkers between the vessel wall and a variety of vascular components (i.e. endothelial cells, platelets, red blood cells) in acute and chronic inflammatory conditions to mediate interactions that can result in vascular injury and vasoocclusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.