Evidence map›Paper›PMID 19923791›Full record

ReviewGerontology2010

Molecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review.

Tamara L Tal, Jill A Franzosa, Robert L Tanguay

Open access · bronzeAbstract readReview
In one paragraph

Review in Gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 76 citations in OpenAlex.

  1. Frontiers in veterinary science · 2026
    Article
  2. Inhibition of Fin Regeneration in Fathead Minnow (Environmental science & technology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. A nontoxic fungal natural product modulates fin regeneration in zebrafish larvae upstream of FGF-WNT developmental signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  7. Article
  8. Article
  9. Chemical science · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tamara L TalDepartment of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, 97331-7301, USA.
Jill A Franzosa
Robert L Tanguay
Oregon State University · US

Funding

Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
NIEHS NIH HHS ES00210NIEHS NIH HHS P30 ES000210NIEHS NIH HHS T32 ES007060NIEHS NIH HHS T32 ES07060
6 · The paper itself

Abstract

This short review provides a current synopsis of caudal fin regeneration in zebrafish with an emphasis on the molecular signaling networks that dictate epimorphic regeneration. At the outset, the fundamentals of caudal fin architecture and the stages of epimorphic regeneration are described. This is followed by a detailed look at the main networks implicated in fin regeneration, namely the Wnt, fibroblast growth factor, activin-betaA, retinoic acid and hedgehog signaling pathways. Throughout this mini-review, these molecular networks are examined through the lens of wound healing, blastema formation or regenerative outgrowth, three of the main stages of epimorphic regeneration. Next, the emerging role of noncoding RNAs as regulators of regeneration and mechanisms of regenerative termination are discussed. Finally, the implications for future research and the broader field of regenerative medicine are examined.

Indexed as

AnimalsAnimal Structuresbeta CateninFibroblast Growth FactorsHedgehog ProteinsMesenchymal Stem CellsModels, BiologicalMultipotent Stem CellsRegenerationRNA, UntranslatedSignal TransductionTretinoinWnt ProteinsWound HealingZebrafishZebrafish Proteinsbeta Cateninctnnb1 protein, zebrafishFibroblast Growth FactorsHedgehog ProteinsRNA, UntranslatedTretinoinWnt ProteinsZebrafish Proteins

Identifiers

PMID19923791
PMCPMC2969159
OpenAlexW2029947113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.