Trial reportRespiration; international review of thoracic diseases2010
A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.
Trial report in Respiration; international review of thoracic diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03010449 (A Single Arm Pilot Study of Lung Volume Reduction in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single Arm Pilot Study of Lung Volume Reduction in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Pooled it
- Endobronchial valves in treatment of persistent air leaks: a systematic review of clinical evidence.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Efficacy of bronchoscopic lung volume reduction: a meta-analysis.International journal of chronic obstructive pulmonary disease · 2014Pooled it
- Expert Statement: Pneumothorax Associated with One-Way Valve Therapy for Emphysema: 2020 Update.Respiration; international review of thoracic diseasesGuideline
- A randomised trial of lung sealant versus medical therapy for advanced emphysema.The European respiratory journal · 2015Trial
- Characterization and detection of physiologic lung changes before and after placement of bronchial valves using hyperpolarized helium-3 MR imaging: preliminary study.Academic radiology · 2011Trial
- Connecting the dots: historical perspective on lung volume reduction.Journal of thoracic disease · 2026Review
- Endobronchial Valves for Bronchoscopic Lung Volume Reduction in Severe Emphysema: A Reversible and Non-Surgical Treatment for Patients Who May or May Not Be Candidates for Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- Endobronchial valves for severe emphysema.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Endobronchial coils in treatment of advanced emphysema: A single center experience.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- Endobronchial valves for persistent air leak all-cause mortality and financial impact: US trend from 2012-2016.Journal of community hospital internal medicine perspectives · 2019Article
- Bronchoscopic treatment of emphysema: an update.Journal of thoracic disease · 2018Review
- Valve therapy in patients with emphysematous type of chronic obstructive pulmonary disease (COPD): from randomized trials to patient selection in clinical practice.Journal of thoracic disease · 2018Review
- Bronchoscopic valves for prolonged air leak: current status and technique.Journal of thoracic disease · 2017Review
- Coil therapy for patients with severe emphysema and bilateral incomplete fissures - effectiveness and complications after 1-year follow-up: a single-center experience.International journal of chronic obstructive pulmonary disease · 2017Article
- Endobronchial valves for bronchopleural fistula: pitfalls and principles.Therapeutic advances in respiratory disease · 2017Article
- Update on Nonsurgical Lung Volume Reduction Procedures.Canadian respiratory journal · 2016Review
- Effects of bronchoscopic lung volume reduction using transbronchial infusion of autologous blood and thrombin in patients with severe chronic obstructive pulmonary disease.Journal of thoracic disease · 2015Article
- Efficacy and safety of endobronchial valves for advanced emphysema: a meta analysis.Journal of thoracic disease · 2015Article
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) affects millions of people and has limited treatment options. Surgical treatments for severe COPD with emphysema are effective for highly selected patients. A minimally invasive method for treating emphysema could decrease morbidity and increase acceptance by patients.
objectiveTo study the safety and effectiveness of the IBV(R) Valve for the treatment of severe emphysema.
methodsA multicenter study treated 91 patients with severe obstruction, hyperinflation and upper lobe (UL)-predominant emphysema with 609 bronchial valves placed bilaterally into ULs.
resultsValves were placed in desired airways with 99.7% technical success and no migration or erosion. There were no procedure-related deaths and 30-day morbidity and mortality were 5.5 and 1.1%, respectively. Pneumothorax was the most frequent serious device-related complication and primarily occurred when all segments of a lobe, especially the left UL, were occluded. Highly significant health-related quality of life (HRQL) improvement (-8.2 +/- 16.2, mean +/- SD change at 6 months) was observed. HRQL improvement was associated with a decreased volume (mean -294 +/- 427 ml, p = 0.007) in the treated lobes without visible atelectasis. FEV(1), exercise tests, and total lung volume were not changed but there was a proportional shift, a redirection of inspired volume to the untreated lobes. Combined with perfusion scan changes, this suggests that there is improved ventilation and perfusion matching in non-UL lung parenchyma.
conclusionBronchial valve treatment of emphysema has multiple mechanisms of action and acceptable safety, and significantly improves quality of life for the majority of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.