ArticleJournal of clinical microbiology2010
Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Molecular Epidemiology ofInternational journal of molecular sciences · 2025Pooled it
- Mass drug administration with azithromycin for trachoma elimination and the population structure of Streptococcus pneumoniae in the nasopharynx.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
- Periodic cycles of pneumococcal serotypes carried by children before and after 7-valent pneumococcal conjugate vaccine.PloS one · 2017Article
- Serotypes and genotypes of Streptococcus pneumoniae isolates from Trinidad and Tobago.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Article
- Comparative Genomics of Carriage and Disease Isolates of Streptococcus pneumoniae Serotype 22F Reveals Lineage-Specific Divergence and Niche Adaptation.Genome biology and evolution · 2016Article
- Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003-2013.Emerging infectious diseases · 2016Article
- Serotypes and genotypes of invasive pneumococci in the central part of Slovenia.Wiener klinische Wochenschrift · 2015Article
- Temporal trends and clonal diversity of penicillin non-susceptible pneumococci from meningitis cases from 1996 to 2012, in Salvador, Brazil.BMC infectious diseases · 2015Article
- Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.PLoS pathogens · 2015Article
- Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.Vaccine · 2015Article
- Article
- Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England.Epidemiology and infection · 2013Article
- Population genetic structure of Streptococcus pneumoniae in Kilifi, Kenya, prior to the introduction of pneumococcal conjugate vaccine.PloS one · 2013Article
- Multiple-locus variable-number tandem-repeat analysis of Streptococcus pneumoniae and comparison with multiple loci sequence typing.BMC microbiology · 2012Article
- Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types.Journal of medical microbiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United Kingdom. We monitored the population of invasive pneumococci in Scotland in the 5 years preceding the introduction of PCV7 by using serogrouping, multilocus sequence typing (MLST), and eBURST analysis. Here, we present a unique analysis of a complete national data set of invasive pneumococci over this time. We observed an increase in invasive pneumococcal disease (IPD) caused by serotypes 1, 4, and 6 and a decrease in serogroup 14-, 19-, and 23-associated disease. Analysis of sequence type (ST) data shows a significant increase in ST306, associated with serotype 1, and a decrease in ST124, associated with serotype 14. There have also been increases in the amounts of IPD caused by ST227 (serotype 1) and ST53 (serotype 8), although these increases were not found to reach significance (P = 0.08 and 0.06, respectively). In the course of the study period preceding the introduction of PCV7, we observed considerable and significant changes in serogroup and clonal distribution over time.
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Registered trials
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