ArticleJournal of clinical microbiology2010
Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Non-neuronal sites of latency for alphaherpesviruses.Journal of virology · 2026Review
- Differential diagnosis of perianal herpes: sexual abuse or autoinoculation?Forensic science, medicine, and pathology · 2026Article
- Framing and understanding the whole aspect of oral sex from social and health perspectives: a narrative review.F1000Research · 2022Review
- Mixing It Up: New Insights Into Interspecies Recombination Between Herpes Simplex Virus Type 1 and 2.The Journal of infectious diseases · 2020Article
- The global and regional burden of genital ulcer disease due to herpes simplex virus: a natural history modelling study.BMJ global health · 2020Article
- Comparison of HEp-2 and Vero Cell Responses Reveal Unique Proapoptotic Activities of the Herpes Simplex Virus Type 1 α0 Gene Transcript and Product.Frontiers in microbiology · 2019Article
- Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.Clinical and experimental immunology · 2018Article
- First estimates of the global and regional incidence of neonatal herpes infection.The Lancet. Global health · 2017Article
- Herpes Genitalis: Diagnosis, Treatment and Prevention.Geburtshilfe und Frauenheilkunde · 2016Review
- Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions.Journal of virology · 2016Article
- Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.Antimicrobial agents and chemotherapy · 2016Article
- Article
- Optimal management of genital herpes: current perspectives.Infection and drug resistance · 2016Review
- Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.Journal of virology · 2015Article
- Designing novel and simple competitive internal amplification control for reliable PCR diagnosis of herpes simplex virus.Jundishapur journal of microbiology · 2015Article
- Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012.PloS one · 2015Article
- Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012.PloS one · 2015Article
- Genital infection with herpes simplex virus types 1 and 2 in women from natal, Brazil.ISRN obstetrics and gynecology · 2014Article
- HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice.Virus research · 2013Article
- High-purity preparation of HSV-2 vaccine candidate ACAM529 is immunogenic and efficacious in vivo.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex virus types 1 and 2 (HSV-1 and -2) are significant human pathogens causing clinically indistinguishable facial and genital lesions. Recently, the number of reported genital herpes cases caused by type 1 virus has increased. Identifying the HSV type is of clinical importance to determine proper treatment, as there is no licensed vaccine or cure. We assessed, by PCR, the frequency of HSV-1 and HSV-2 present in more than 60,000 clinical cervicovaginal specimens derived from samples originating from 43 continental U.S. states. Fourteen percent were positive for HSV-1 and/or HSV-2. This likely represents subclinal shedding. It was not a measurement of the prevalence of HSV infection. While the majority were HSV-2, 32% were HSV-1. The distribution of HSV types varied between the states with the largest number of specimens, New Jersey, Florida, and Texas. Specimens from women under the age of 24 had an HSV-1 positivity rate of 47 percent. Importantly, in New Jersey, an observed age effect was the disproportionately high prevalence of genital HSV-1 in young women. This represents the largest analysis of HSV types reported and has important public health implications, particularly for younger women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.