ArticleJournal of clinical microbiology2010
Asymptomatic Leishmania infantum infection in an area of northwestern Italy (Piedmont region) where such infections are traditionally nonendemic.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- The utility of pathogen inactivation technology: a real-life example of Leishmania infantum inactivation in platelets from a donor with an asymptomatic infection.Blood transfusion = Trasfusione del sangue · 2012Trial
- Seasonal trends of sand fly abundance andOne health (Amsterdam, Netherlands) · 2025Article
- Delayed diagnosis among patients with visceral leishmaniasis.Internal and emergency medicine · 2023Observational
- Prevalence of asymptomatic Leishmania infection and knowledge, perceptions, and practices in blood donors in mainland Portugal.Parasites & vectors · 2023Article
- The estimated distribution of autochthonous leishmaniasis by Leishmania infantum in Europe in 2005-2020.PLoS neglected tropical diseases · 2023Review
- Fifty Years of Wildlife Diseases in Europe: A Citation Database Meta-Analysis.Veterinary sciences · 2022Article
- A Convenient and Sensitive kDNA-PCR for Screening of Leishmania infantum Latent Infection Among Blood Donors in a Highly Endemic Focus, Northwestern Iran.Acta parasitologica · 2022Article
- Distribution of Phlebotomine Sand Flies (Diptera: Psychodidae) in the Lombardy Region, Northern Italy.Insects · 2022Article
- Prognostic Value of Immunoglobulin G (IgG) Patterns by Western Blotting Immunodetection in Treated Dogs Previously Infected withVeterinary sciences · 2021Article
- Feline Leishmaniosis in Northwestern Italy: Current Status and Zoonotic Implications.Veterinary sciences · 2021Article
- Simultaneous Exposure toPathogens (Basel, Switzerland) · 2021Article
- Feline Leishmaniosis: An Emerging Public Health Problem.Veterinary sciences · 2021Review
- Screening strategies for the diagnosis of asymptomatic Leishmania infection in dialysis patients as a model for kidney transplant candidates.Journal of nephrology · 2021Article
- Clinical Misdiagnosis of COVID-19 Infection with Confusing Clinical Course.Case reports in infectious diseases · 2021Article
- Integrating environmental, entomological, animal, and human data to model theOne health (Amsterdam, Netherlands) · 2020Article
- Serodiagnosis of Visceral Leishmaniasis in Northeastern Italy: Evaluation of Seven Serological Tests.Microorganisms · 2020Article
- Xenodiagnosis to address key questions in visceral leishmaniasis control and elimination.PLoS neglected tropical diseases · 2020Review
- Leishmania infantum and Dirofilaria immitis infections in Italy, 2009-2019: changing distribution patterns.Parasites & vectors · 2020Article
- Evaluation of six commercial kits for the serological diagnosis of Mediterranean visceral leishmaniasis.PLoS neglected tropical diseases · 2020Article
- Place of Serology in the Diagnosis of Zoonotic Leishmaniases With a Focus on Visceral Leishmaniasis Due toFrontiers in cellular and infection microbiology · 2020Review
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6 authors.
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Abstract
The prevalence of Leishmania infantum-specific antibodies and asymptomatic infection was assessed in a randomized sample of 526 healthy adults from a continental area of northwestern Italy where L. infantum is not endemic and where autochthonous cases of visceral leishmaniasis (VL) were recently reported. L. infantum-specific antibodies were detected by Western blotting (WB) in 39 subjects (7.41%), while L. infantum kinetoplast DNA was amplified from buffy coat in 21 out of 39 WB-positive subjects, confirming asymptomatic infection in 53.8% of seropositives. Risk factors significantly associated with WB positivity were uninterrupted residence since childhood in a local rural environment (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.7 to 7.3), daily contact with animals though not exclusively with dogs (OR, 3.7; 95% CI, 1.3 to 10.7), older age (OR, 2.31; 95% CI, 1.2 to 4.5), and agricultural/other outdoor activities (OR, 3.8; 95% CI, 0.99 to 3.7.) Logistic regression analysis showed that uninterrupted residence in a local rural environment and an age of >65 years were the only independent predictors of seropositivity assessed by WB. Follow-up at 24 months did not show evidence of VL in either seropositive or PCR-positive subjects. The detection of a high seroprevalence rate, confirmed as asymptomatic infection by PCR in more than half of the cases, among healthy residents in a continental area of northwestern Italy makes local L. infantum transmission very likely. In a region where VL is considered nonendemic, these findings warrant further epidemiological investigations as well as interventions with respect to both the canine reservoir and vectors, given the possible risks for immunosuppressed patients.
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