ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Functional heterogeneity at dopamine release sites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry.Advances in neurobiology · 2025Review
- Mechanisms of neuromodulatory volume transmission.Molecular psychiatry · 2024Review
- Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta.Frontiers in neuroanatomy · 2024Article
- Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington's disease.Frontiers in molecular neuroscience · 2023Article
- Article
- A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Spatial and temporal scales of dopamine transmission.Nature reviews. Neuroscience · 2021Review
- Targeting the cholinergic system in Parkinson's disease.Acta pharmacologica Sinica · 2020Review
- Mechanisms and regulation of dopamine release.Current opinion in neurobiology · 2019Review
- Altered Synaptic Vesicle Release and CaFrontiers in molecular neuroscience · 2018Article
- Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum.Nature neuroscience · 2016Article
- Rapid genotyping of animals followed by establishing primary cultures of brain neurons.Journal of visualized experiments : JoVE · 2015Article
- Fast phasic release properties of dopamine studied with a channel biosensor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening.Nature protocols · 2012Article
- Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Article
- Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors.Basal ganglia · 2012Article
- Dopamine release in the basal ganglia.Neuroscience · 2011Review
- Functional reorganization of the presynaptic dopaminergic terminal in parkinsonism.Neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Although drugs used to treat several neurological diseases are presumed to target synapses that secrete dopamine (DA), relatively little is known about synaptic vesicle (SV) release mechanisms at single DA synapses. We found that the relative probability of release (Pr) varied between individual DA synapses. Furthermore, DA terminals generally exhibited lower Pr than glutamatergic hippocampal (Hpc) terminals, suggesting that DA release is less reliable than the release of glutamate. Our mathematical model of fluorescence loss shows that Pr is regulated by two independent and heterogeneous elements. First, the size of the recycling SV pool regulates Pr. Second, Pr is also independently regulated by additional factors, which are reflected in the time constant of FM 1-43 destaining, tau. We found that the observed difference in Pr between Hpc and DA neurons results because the recycling SV pool is smaller in DA neurons than in Hpc neurons. However, tau does not vary between these two neuron populations. We also identified a population of functional nonsynaptic boutons in DA axons, which are not associated with a postsynaptic element and which are not functionally different from boutons that formed conventional synapses. Our work provides a new approach to the study of SV exocytosis in DA neurons and shows that synaptic terminals of DA neurons are functionally heterogeneous and differ from excitatory terminals in terms of Pr.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.