ArticleJournal of neurophysiology2010
Experimental mild traumatic brain injury induces functional alteration of the developing hippocampus.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Information and communication technology to support self-management of patients with mild acquired cognitive impairments: systematic review.Journal of medical Internet research · 2012Pooled it
- Cyclosporine A Accelerates Neurorecovery Transcriptional Trajectory in a Swine Model of Diffuse Traumatic Brain Injury.International journal of molecular sciences · 2025Article
- Partial Depletion of Microglia Attenuates Long-Term Potentiation Deficits following Repeated Blast Traumatic Brain Injury in Organotypic Hippocampal Slice Cultures.Journal of neurotrauma · 2023Article
- Mechanical injury and blood are drivers of spatial memory deficits after rapid intraventricular hemorrhage.Neurobiology of disease · 2020Article
- Classifying mild traumatic brain injuries with functional network analysis.BMC systems biology · 2018Article
- Method for High Speed Stretch Injury of Human Induced Pluripotent Stem Cell-derived Neurons in a 96-well Format.Journal of visualized experiments : JoVE · 2018Article
- Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast.Experimental neurology · 2017Article
- Assessment of cognitive dysfunction in traumatic brain injury patients: a review.Forensic sciences research · 2017Review
- Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury.Scientific reports · 2016Article
- Isolated Primary Blast Inhibits Long-Term Potentiation in Organotypic Hippocampal Slice Cultures.Journal of neurotrauma · 2016Article
- Alterations in Hippocampal Network Activity after In Vitro Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury.Neural regeneration research · 2015Article
- The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden.Journal of biomechanical engineering · 2014Review
- Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects.Frontiers in neurology · 2013Article
- Encapsulating Elastically Stretchable Neural Interfaces: Yield, Resolution, and Recording/Stimulation of Neural Activity.Advanced functional materials · 2012Article
- Combining the finite element method with structural connectome-based analysis for modeling neurotrauma: connectome neurotrauma mechanics.PLoS computational biology · 2012Article
- Dynamic changes in neural circuit topology following mild mechanical injury in vitro.Annals of biomedical engineering · 2012Article
- Biomechanics of concussion.Clinics in sports medicine · 2011Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is estimated that approximately 1.5 million Americans suffer a traumatic brain injury (TBI) every year, of which approximately 80% are considered mild injuries. Because symptoms caused by mild TBI last less than half an hour by definition and apparently resolve without treatment, the study of mild TBI is often neglected resulting in a significant knowledge gap for this wide-spread problem. In this work, we studied functional (electrophysiological) alterations of the neonatal/juvenile hippocampus after experimental mild TBI. Our previous work reported significant cell death after in vitro injury >10% biaxial deformation. Here we report that biaxial deformation as low as 5% affected neuronal function during the first week after in vitro mild injury of hippocampal slice cultures. These results suggest that even very mild mechanical events may lead to a quantifiable neuronal network dysfunction. Furthermore, our results highlight that safe limits of mechanical deformation or tolerance criteria may be specific to a particular outcome measure and that neuronal function is a more sensitive measure of injury than cell death. In addition, the age of the tissue at injury was found to be an important factor affecting posttraumatic deficits in electrophysiological function, indicating a relationship between developmental status and vulnerability to mild injury. Our findings suggest that mild pediatric TBI could result in functional deficits that are more serious than currently appreciated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.