ArticleThe Journal of biological chemistry2010
The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 75 citations in OpenAlex.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Host Transcriptomics Reveal Reduction in Defence-Reproduction Trade-Offs During Coinfection.Molecular ecology · 2025Article
- Calcineurin inhibition enhanceseLife · 2024Article
- SICKO: Systematic Imaging ofbioRxiv : the preprint server for biology · 2024Article
- Decoding lifespan secrets: the role of the gonad inFrontiers in aging · 2024Review
- Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response.Nature communications · 2023Article
- piRNAs regulate a Hedgehog germline-to-soma pro-aging signal.Nature aging · 2023Article
- A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.Frontiers in immunology · 2023Article
- Immunosenescence in Caenorhabditis elegans.Immunity & ageing : I & A · 2022Article
- Transcriptomic evidence for a trade-off between germline proliferation and immunity inEvolution letters · 2021Article
- Article
- Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop.The Journal of cell biology · 2021Article
- Article
- The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.Nature communications · 2019Article
- Convergence of longevity and immunity: lessons from animal models.Biogerontology · 2019Review
- Does senescence promote fitness in Caenorhabditis elegans by causing death?Ageing research reviews · 2019Review
- Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway inFrontiers in immunology · 2018Article
- Good Ol' Fat: Links between Lipid Signaling and Longevity.Trends in biochemical sciences · 2017Review
- Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The relationship between the mechanisms that control an organism's lifespan and its ability to respond to environmental challenges are poorly understood. In Caenorhabditis elegans, an insulin-like signaling pathway modulates lifespan and the innate immune response to bacterial pathogens via a common mechanism involving transcriptional regulation by the DAF-16/FOXO transcription factor. The C. elegans germ line also modulates lifespan in a daf-16-dependent manner. Here, we show that the germ line controls the innate immune response of C. elegans somatic cells to two different Gram-negative bacteria. In contrast to the insulin-like signaling pathway, the germ line acts via distinct signaling pathways to control lifespan and innate immunity. Under standard nematode culture conditions, the germ line regulates innate immunity in parallel to a known p38 MAPK signaling pathway, via a daf-16-independent pathway. Our findings indicate that a complex regulatory network integrates inputs from insulin-like signaling, p38 MAPK signaling, and germ line stem cells to control innate immunity in C. elegans. We also confirm that innate immunity and lifespan in C. elegans are distinct processes, as nonoverlapping regulatory networks control survival in the presence of pathogenic and nonpathogenic bacteria. Finally, we demonstrate that the p38 MAPK pathway in C. elegans is activated to a similar extent by both pathogenic and nonpathogenic bacteria, suggesting that both can induce the nematode innate immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.