Evidence map›Paper›PMID 19922750›Full record

ReviewAdvanced drug delivery reviews2010

Application of nanotechnologies for improved immune response against infectious diseases in the developing world.

Michael Look, Arunima Bandyopadhyay, Jeremy S Blum, Tarek M Fahmy

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. EngineeringVaccines · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Advancements in protein nanoparticle vaccine platforms to combat infectious disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  15. Effect of physicochemical properties onActa pharmaceutica Sinica. B · 2021
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael LookDepartment of Biomedical Engineering, New Haven, CT 06520-8260, USA.
Arunima Bandyopadhyay
Jeremy S Blum
Tarek M Fahmy

Funding

IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
Semiconductor Nanosensors for Label-Free Detection of Antigens and Cellular ImmunR01EB008260 · NIBIB · YALE UNIVERSITY · PI FAHMY, TAREK, REED, MARK · 2007 to 2010
$1.5M
DNA Immunization in the Female Genital Tract Using A Controlled Delivery MatrixF32AI072942 · NIAID · YALE UNIVERSITY · PI BLUM, JEREMY S · 2008 to 2009
$108k
NHLBI NIH HHS 5T32 HL007974-08NHLBI NIH HHS T32 HL007974NIAID NIH HHS F32 AI072942NIAID NIH HHS F32AI072942NIBIB NIH HHS R01 EB008260
6 · The paper itself

Abstract

There is an urgent need for new strategies to combat infectious diseases in developing countries. Many pathogens have evolved to elude immunity and this has limited the utility of current therapies. Additionally, the emergence of co-infections and drug resistant pathogens has increased the need for advanced therapeutic and diagnostic strategies. These challenges can be addressed with therapies that boost the quality and magnitude of an immune response in a predictable, designable fashion that can be applied for wide-spread use. Here, we discuss how biomaterials and specifically nanoscale delivery vehicles can be used to modify and improve the immune system response against infectious diseases. Immunotherapy of infectious disease is the enhancement or modulation of the immune system response to more effectively prevent or clear pathogen infection. Nanoscale vehicles are particularly adept at facilitating immunotherapeutic approaches because they can be engineered to have different physical properties, encapsulated agents, and surface ligands. Additionally, nanoscaled point-of-care diagnostics offer new alternatives for portable and sensitive health monitoring that can guide the use of nanoscale immunotherapies. By exploiting the unique tunability of nanoscale biomaterials to activate, shape, and detect immune system effector function, it may be possible in the near future to generate practical strategies for the prevention and treatment of infectious diseases in the developing world.

Indexed as

Developing CountriesAdjuvants, ImmunologicChronic DiseaseHumansImmune SystemImmunityImmunologic FactorsInfection ControlNanotechnologyVaccinationAdjuvants, ImmunologicImmunologic Factors

Identifiers

PMID19922750
PMCPMC2880812

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.