Trial reportBMC geriatrics2009
Inverse association between insulin resistance and gait speed in nondiabetic older men: results from the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2002.
Trial report in BMC geriatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial.Experimental gerontology · 2021Trial
- Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population.Scientific reports · 2019Trial
- Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants.Journal of the American Geriatrics Society · 2015Trial
- Insulin resistance and sarcopenia: independent and combined associations with obesity and dietary protein intake.Journal of endocrinological investigation · 2026Article
- The bidirectional relationship between diabetes and poor muscle function in older adults: data from two population-based studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Effect of type‑II diabetes mellitus on swallowing difficulty, swallowing anxiety, laryngeal function, and water swallowing performance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Sex-Dependent Effects of Aging and Insulin Resistance on Skeletal Muscle Function and Structure in Rats.International journal of molecular sciences · 2025Article
- Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in Reducing Events in the Elderly Study.GeroScience · 2025Observational
- Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988-1994 and 1999-2018.Aging medicine (Milton (N.S.W)) · 2024Article
- Gender-specific capacity of insulin resistance proxies to predict functional decline in older adults.The journal of nutrition, health & aging · 2024Article
- Association between gait video information and general cardiovascular diseases: a prospective cross-sectional study.European heart journal. Digital health · 2024Article
- Association Between Metformin Use and Cognitive and Physical Function in Persons with HIV and Diabetes.AIDS research and human retroviruses · 2023Observational
- Factors of Muscle Quality and Determinants of Muscle Strength: A Systematic Literature Review.Healthcare (Basel, Switzerland) · 2022Review
- Dual effects of insulin resistance on mortality and function in non-diabetic older adults: findings from the Toledo Study of Healthy Aging.GeroScience · 2022Article
- Sex-Specific Associations Between Low Muscle Mass and Glucose Fluctuations in Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2022Article
- Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study.Journal of diabetes investigation · 2021Article
- Relationship of Multimorbidity, Obesity Status, and Grip Strength among Older Adults in Taiwan.International journal of environmental research and public health · 2021Article
- Sex differences in sarcopenia and frailty among community-dwelling Korean older adults with diabetes: The Korean Frailty and Aging Cohort Study.Journal of diabetes investigation · 2021Article
- Swallowing dıfficulty and swallowing anxiety in patients with type-II diabetes mellitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have revealed the associations between insulin resistance (IR) and geriatric conditions such as frailty and cognitive impairment. However, little is known about the relation of IR to physical impairment and limitation in the aging process, eg. slow gait speed and poor muscle strength. The aim of this study is to determine the effect of IR in performance-based physical function, specifically gait speed and leg strength, among nondiabetic older adults.
methodsCross-sectional data were from the population-based National Health and Nutrition Examination Survey (1999-2002). A total of 1168 nondiabetic adults (> or = 50 years) with nonmissing values in fasting measures of insulin and glucose, habitual gait speed (HGS), and leg strength were analyzed. IR was assessed by homeostasis model assessment (HOMA-IR), whereas HGS and peak leg strength by the 20-foot timed walk test and an isokinetic dynamometer, respectively. We used multiple linear regression to examine the association between IR and performance-based physical function.
resultsIR was inversely associated with gait speed among the men. After adjusting demographics, body mass index, alcohol consumption, smoking status, chronic co-morbidities, and markers of nutrition and cardiovascular risk, each increment of 1 standard deviation in the HOMA-IR level was associated with a 0.04 m/sec decrease (p = 0.003) in the HGS in men. We did not find such association among the women. The IR-HGS association was not changed after further adjustment of leg strength. Last, HOMA-IR was not demonstrated in association with peak leg strength.
conclusionIR is inversely associated with HGS among older men without diabetes. The results suggest that IR, an important indicator of gait function among men, could be further investigated as an intervenable target to prevent walking limitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.