ArticleVirology journal2009
Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patient.
Article in Virology journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mixed Infections Unravel Novel HCV Inter-Genotypic Recombinant Forms within the Conserved IRES Region.Viruses · 2024Article
- High recombination rate of hepatitis C virus revealed by a green fluorescent protein reconstitution cell system.Virus evolution · 2022Article
- Implementation of Microelimination Strategy in Eradication of Chronic Hepatitis C Infection in Patients with Hemophilia in the Northern region of Serbia: Is Eradication Possible?Mediterranean journal of hematology and infectious diseases · 2021Article
- Hepatitis C virus genotype 1 and 2 recombinant genomes and the phylogeographic history of the 2k/1b lineage.Virus evolution · 2019Article
- Identification of a putative novel genotype 3/rabbit hepatitis E virus (HEV) recombinant.PloS one · 2018Article
- Characterization of Hepatitis C Virus Recombination in Cameroon by Use of Nonspecific Next-Generation Sequencing.Journal of clinical microbiology · 2015Article
- Hepatitis C virus genetic variability and evolution.World journal of hepatology · 2015Review
- Hepatitis C virus NS3 mutations in haemophiliacs.Haemophilia : the official journal of the World Federation of Hemophilia · 2014Article
- Ultradeep pyrosequencing of hepatitis C virus hypervariable region 1 in quasispecies analysis.BioMed research international · 2013Article
- Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis.Journal of virology · 2013Article
- Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k/1b.Journal of virology · 2012Article
- Molecular characterization of a porcine astrovirus strain in China.Archives of virology · 2011Article
- Recombination in hepatitis C virus.Viruses · 2011Review
- Analysis of the genomic homologous recombination in Theilovirus based on complete genomes.Virology journal · 2011Article
- Near-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis C virus isolates.Advances in virology · 2011Article
- Recombination analysis reveals a double recombination event in hepatitis E virus.Virology journal · 2010Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimHepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders. HCV, as others RNA virus, exploit all possible mechanisms of genetic variation to ensure their survival, such as recombination and mutation. In order to gain insight into the genetic variability of HCV virus strains circulating in hemophiliac patients, we have performed a phylogenetic analysis of HCV strains isolated from 10 patients with this kind of pathology.
methodsPutative recombinant sequence was identified with the use of GARD program. Statistical support for the presence of a recombination event was done by the use of LARD program.
resultsA new intragenotypic recombinant strain (1b/1a) was detected in 1 out of the 10 hemophiliac patient studied. The recombination event was located at position 387 of the HCV genome (relative to strain AF009606, sub-type 1a) corresponding to the core gene region.
conclusionAlthough recombination may not appear to be common among natural populations of HCV it should be considered as a possible mechanism for generating genetic diversity in hemophiliacs patients.
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