ArticleBMC genomics2009
The isochore patterns of invertebrate genomes.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Inference of genomic landscapes using ordered Hidden Markov Models with emission densities (oHMMed).BMC bioinformatics · 2024Article
- De Novo Genome Assembly at Chromosome-Scale ofInsects · 2024Article
- Abandoning the Isochore Theory Can Help Explain Genome Compositional Organization in Fish.International journal of molecular sciences · 2023Article
- The "Genomic Code": DNA Pervasively Moulds Chromatin Structures Leaving no Room for "Junk".Life (Basel, Switzerland) · 2021Review
- Comparative Gene Mapping as a Tool to Understand the Evolution of Pest Crop Insect Chromosomes.International journal of molecular sciences · 2017Article
- The Isochores as a Fundamental Level of Genome Structure and Organization: A General Overview.Journal of molecular evolution · 2017Review
- An Isochore-Like Structure in the Genome of the Flatworm Schistosoma mansoni.Genome biology and evolution · 2016Article
- The Anolis Lizard Genome: An Amniote Genome without Isochores?Genome biology and evolution · 2016Article
- Chromosome Architecture and Genome Organization.PloS one · 2015Article
- Segmenting the Human Genome into Isochores.Evolutionary bioinformatics online · 2015Article
- A comparative study and a phylogenetic exploration of the compositional architectures of mammalian nuclear genomes.PLoS computational biology · 2014Article
- Compositional patterns in the genomes of unicellular eukaryotes.BMC genomics · 2013Article
- Unlocking holocentric chromosomes: new perspectives from comparative and functional genomics?Current genomics · 2012Article
- Large homogeneous genome regions (isochores) in soybean [glycine max (L.) merr].Frontiers in genetics · 2012Article
- GC3 biology in corn, rice, sorghum and other grasses.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious investigations from our laboratory were largely focused on the genome organization of vertebrates. We showed that these genomes are mosaics of isochores, megabase-size DNA sequences that are fairly homogeneous in base composition yet belong to a small number of families that cover a wide compositional spectrum. A question raised by these results concerned how far back in evolution an isochore organization of the eukaryotic genome arose.
resultsThe present investigation deals with the compositional patterns of the invertebrates for which full genome sequences, or at least scaffolds, are available. We found that (i) a mosaic of isochores is the long-range organization of all the genomes that we investigated; (ii) the isochore families from the invertebrate genomes matched the corresponding families of vertebrates in GC levels; (iii) the relative amounts of isochore families were remarkably different for different genomes, except for those from phylogenetically close species, such as the Drosophilids.
conclusionThis work demonstrates not only that an isochore organization is present in all metazoan genomes analyzed that included Nematodes, Arthropods among Protostomia, Echinoderms and Chordates among Deuterostomia, but also that the isochore families of invertebrates share GC levels with the corresponding families of vertebrates.
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