ArticleJournal of thrombosis and haemostasis : JTH2010
Effects of inhalable particulate matter on blood coagulation.
Article in Journal of thrombosis and haemostasis : JTH, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.Reviews on environmental health · 2012Pooled it
- Gene-air pollution interaction and cardiovascular disease: a review.Progress in cardiovascular diseasesPooled it
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- Air Pollution and Cardiovascular and Thromboembolic Events in Older Adults With High-Risk Conditions.American journal of epidemiology · 2023Article
- Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health).Environment international · 2023Article
- Computational Fluid Dynamics Study of the Effects of Temperature and Geometry Parameters on a Virtual Impactor.Micromachines · 2022Article
- The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A Review of the Invisible Killer.Nanomaterials (Basel, Switzerland) · 2022Review
- Towards a toxic-free environment: perspectives for chemical risk assessment approaches.La Medicina del lavoro · 2022Article
- Association of PMScientific reports · 2021Article
- Review
- [Air pollution and cardiovascular diseases].Herz · 2021Review
- Influence of weather and air pollution on the occurrence of idiopathic pulmonary embolism in the region of Sousse (Tunisia).Environmental science and pollution research international · 2020Article
- Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution.Journal of the American Heart Association · 2020Review
- The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory Investigation.Frontiers in genetics · 2020Article
- Novel evidence for a greater burden of ambient air pollution on cardiovascular disease.Haematologica · 2019Review
- Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz.International archives of occupational and environmental health · 2019Article
- Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway.Particle and fibre toxicology · 2019Article
- Effects of Cardiorespiratory Exercise on Cognition in Older Women Exposed to Air Pollution.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundParticulate matter (PM) exposure has been linked to increased risk of cardiovascular disease, possibly resulting from hypercoagulability and thrombosis. Lung and systemic inflammation resulting from PM inhalation may activate blood coagulation, but mechanisms for PM-related hypercoagulability are still largely unknown.
objectivesTo identify coagulation mechanisms activated by PM in a population with well-characterized exposure.
methodsWe measured prothrombin time (PT), activated partial thromboplastin time, endogenous thrombin potentials (ETPs) with/without exogenous triggers and with/without soluble thrombomodulin, tissue-type plasminogen activator (t-PA) antigen, D-dimer and C-reactive protein (CRP) in 37 workers in a steel production plant with well-characterized exposure to PM with aerodynamic diameter of < 1 mum (PM(1)) and coarse PM (PM(10) - PM(1)). Blood samples were collected from each subject on the first (baseline) and last (postexposure) day of a 4-day work week. We analyzed differences between baseline and postexposure levels using a paired Student's t-test. We fitted multivariate mixed-regression models to estimate the associations of interquartile range PM(1) and coarse PM exposure with parameter levels.
resultsNone of the parameters showed any significant changes from baseline in postexposure samples. However, exposure levels were associated with shorter PT (beta[PM(1)] = -0.33 s, P = 0.08; beta[PM(coarse)] = - 0.33 s, P = 0.01), and higher ETP without exogenous triggers and with thrombomodulin (beta[PM(1)] = + 99 nm min, P = 0.02; beta[PM(coarse)] = + 66 nm min, P = 0.05), t-PA (beta[PM(1)] = + 0.72 ng mL(-1), P = 0.01; beta[PM(coarse)] = + 0.88 ng mL(-1), P = 0.04), and CRP (beta[PM(1)] = + 0.59 mg L(-1), P = 0.03; beta[PM(coarse)] = + 0.48 mg L(-1), P = 0.01).
conclusionsPM exposure did not show any short-term effect within the week of the study. The association of PM exposure with PT, ETP and CRP provides some evidence of long-term effects on inflammation and coagulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.