ArticleImmunology2010
Mesenteric lymph nodes are not required for an intestinal immunoglobulin A response to oral cholera toxin.
Article in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Mesenteric lymph nodes are required for B- but dispensable for local T cell effector responses followingFrontiers in immunology · 2026Article
- All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.Immunological reviews · 2024Review
- Diet-induced obesity results in impaired oral tolerance induction.Immunity, inflammation and disease · 2022Article
- The role of retinoic acid in the production of immunoglobulin A.Mucosal immunology · 2022Review
- Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes.Journal of advanced research · 2020Article
- Article
- IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response.Journal of immunology research · 2018Article
- The regulation of gut mucosal IgA B-cell responses: recent developments.Mucosal immunology · 2017Review
- Plasma cells in primary melanoma. Prognostic significance and possible role of IgA.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Lymph node dissection--understanding the immunological function of lymph nodes.Clinical and experimental immunology · 2012Review
- M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses.BMC biotechnology · 2012Article
- CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance.Immunology · 2012Article
- The role of Peyer's patches in synchronizing gut IgA responses.Frontiers in immunology · 2012Article
- Lymph node transplantation and its immunological significance in animal models.Clinical & developmental immunology · 2011Article
- Dendritic cells in the gut: interaction with intestinal helminths.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of the adaptive immune system in the gut is thought to be mainly initiated in the Peyer's patches as well as in the mesenteric lymph nodes (mLNs) and results in immunoglobulin A (IgA) secretion by plasma cells in the lamina propria. However, the precise role of the mLNs in the development of IgA immune responses is poorly understood. Thus, cholera toxin (CT) was administered to mLN-resected and mLN-bearing animals and the IgA response to CT in the intestine and serum was examined. Levels of CT-specific IgA antibodies and the numbers of cells producing these antibodies in the intestine were increased in mLN-resected rats. Particularly in the distal parts of the intestine, the jejunum and the ileum, IgA responses to orally administered antigens developed were stronger in the intestine after removal of the mLNs. This strongly indicates that the mLNs play a critical role in modulating the expansion of specific IgA responses. After removal of the mLNs, the lymph from the gut flows directly into the blood. It was investigated whether the spleen is involved in the initiation of an immune response to orally administered CT after removal of the mLNs. In the spleens of mLN-resected animals, proliferation was up-regulated, and germinal centres were formed in the follicles. However, CT-specific IgM(+) cells, but no IgA(+) cells, developed. Additionally, an increase of CT-specific IgM in the serum was found in mLN-resected animals. Thus, the data indicate that the spleen is involved in the immune response to CT after mLN resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.