Evidence map›Paper›PMID 19922365›Full record

ArticleThe International journal of neuroscience2009

Critical role of s465 in protein kinase C-increased rat glutamate transporter type 3 activity.

Hee Jung Baik, Yueming Huang, Jacqueline M Washington, Zhiyi Zuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Vesicular and plasma membrane transporters for neurotransmitters.Cold Spring Harbor perspectives in biology · 2012
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hee Jung BaikDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA.
Yueming Huang
Jacqueline M Washington
Zhiyi Zuo

Funding

Volatile anesthetic modulation of glutamate transportersR01GM065211 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZUO, ZHIYI · 2003 to 2011
$2.6M
Neuroprotection after Isoflurane PreconditioningR01NS045983 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZUO, ZHIYI · 2004 to 2007
$1.1M
NIGMS NIH HHS R01 GM065211NINDS NIH HHS R01 NS045983
6 · The paper itself

Abstract

Glutamate transporters, also called excitatory amino acid transporters (EAATs), uptake extracellular glutamate and regulate neurotransmission. Activation of protein kinase C (PKC) increases the activity of EAAT type 3 (EAAT3), the major neuronal EAAT. We designed this study to determine which amino acid residue(s) in EAAT3 may be involved in this PKC effect. Selective potential PKC phosphorylation sites were mutated. These EAAT3 mutants were expressed in the Xenopus oocytes. Phorbol 12-myristate 13-acetate, a PKC activator, significantly increased wild-type EAAT3 activity. Mutation of serine 465 to alanine or aspartic acid, but not the mutation of threonine 5 to alanine, abolished PKC-increased EAAT3 activity. Our results suggest a critical role of serine 465 in the increased EAAT3 activity by PKC activation.

Indexed as

Anesthetics, InhalationAnimalsData Interpretation, StatisticalDNA, ComplementaryElectrophysiologyExcitatory Amino Acid Transporter 3FemaleIsofluraneOocytesPatch-Clamp TechniquesPhorbol EstersPhosphorylationProtein Kinase CRatsSerineTetradecanoylphorbol AcetateAnesthetics, InhalationDNA, ComplementaryExcitatory Amino Acid Transporter 3IsofluranePhorbol EstersProtein Kinase CSerineSlc1a1 protein, ratTetradecanoylphorbol Acetate

Identifiers

PMID19922365
PMCPMC2780444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.