SynthesisInternational urology and nephrology2010
Acute tubular necrosis and pre-renal acute kidney injury: utility of urine microscopy in their evaluation- a systematic review.
Synthesis in International urology and nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- The Utility of Urine Microscopy Score for Early Detection and Prediction of Acute Kidney Injury in At-Risk Patients.Kidney360 · 2025Article
- Flow-Cytometric Quantification of Urine Kidney Epithelial Cells Specifically Reflects Tubular Damage in Acute Kidney Diseases.Kidney international reports · 2025Article
- Evaluation of simple diagnostic parameters in acute kidney injury in hospitalized patients-diagnostic recommendations for non-nephrologists.Internal and emergency medicine · 2023Article
- Identification of Pre-Renal and Intrinsic Acute Kidney Injury by Anamnestic and Biochemical Criteria: Distinct Association with Urinary Injury Biomarkers.International journal of molecular sciences · 2023Article
- MFG-E8-derived peptide attenuates inflammation and injury after renal ischemia-reperfusion in mice.Heliyon · 2020Article
- Urine microscopy as a biomarker of Acute Kidney Injury following cardiac surgery with cardiopulmonary bypass.Jornal brasileiro de nefrologia · 2020Observational
- Is urine microscopy a useful early biomarker for cardiac surgeryrelated AKI?Jornal brasileiro de nefrologia · 2020Article
- Automated urinalysis combining physicochemical analysis, on-board centrifugation, and digital imaging in one system: A multicenter performance evaluation of the cobas 6500 urine work area.Practical laboratory medicine · 2019Article
- The Protective Effect of A Short Peptide Derived From Cold-Inducible RNA-Binding Protein in Renal Ischemia-Reperfusion Injury.Shock (Augusta, Ga.) · 2018Article
- Enhancing the Detection of Dysmorphic Red Blood Cells and Renal Tubular Epithelial Cells with a Modified Urinalysis Protocol.Scientific reports · 2017Article
- Does remifentanil attenuate renal ischemia-reperfusion injury better than dexmedetomidine in rat kidney?Drug design, development and therapy · 2017Article
- Acute Kidney Injury: Diagnostic Approaches and Controversies.The Clinical biochemist. Reviews · 2016Review
- Neutrophil gelatinase-associated lipocalin protects renal tubular epithelial cells in hypoxia-reperfusion by reducing apoptosis.International urology and nephrology · 2014Article
- Bilateral diffuse cystic renal dysplasia in a 9-day-old Thoroughbred filly.The Canadian veterinary journal = La revue veterinaire canadienne · 2014Article
- Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study.Journal of critical care · 2013Article
- Repeated intoxication presenting with azotemia, elevated serum osmolal gap, and metabolic acidosis with high anion gap: differential diagnosis, management, and prognosis.International urology and nephrology · 2012Article
- Acute renal dysfunction in patients with alcoholic hepatitis.World journal of hepatology · 2011Article
- Update on the diagnosis and management of acute kidney injury.International journal of nephrology and renovascular disease · 2010Article
- Ischemic kidney injury and mechanisms of tissue repair.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrine microscopy with examination of the urine sediment examination provides useful diagnostic information about the histology of the kidneys. While most nephrologists use urine microscopy to assess for the presence of glomerular diseases, they are less apt to use this diagnostic test when pre-renal acute kidney injury (AKI) or acute tubular necrosis (ATN) is clinically suspected. More often, tests such as fractional excretion of sodium (FeNa) and fractional excretion of urea (FeUrea) are used to differentiate these two causes of acute kidney injury. DESIGN AND
methodsA systematic search of Medline and the Cochrane Database, with no language restrictions, for studies in humans on urine microscopy with sediment examination for the differential diagnosis or risk stratification of acute kidney injury published between January 1960 and February 2009 was undertaken.
resultsBased on the limited available data on urine microscopy reviewed in this paper, this test has merit in hospitalized patients with acute kidney injury to differentiate between pre-renal acute kidney injury and acute tubular necrosis. The presence and number of renal tubular epithelial cells and renal tubular epithelial cell casts and/or granular casts in the urine sediment appear beneficial in the diagnosis of ATN and may be useful in predicting more severe kidney damage that is reflected by non-recovery of AKI and need for dialysis.
conclusionsUrine microscopy and urine sediment examination is widely available, easy to perform, and inexpensive. The clinical utility of urine microscopy in the differential diagnosis and prediction of outcome in AKI may be increased by using a simple urinary scoring system based on the number of renal tubular epithelial cells and renal tubular epithelial cell/granular casts.
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