ArticleJournal of molecular histology2009
Influence of growth and transcriptional factors, and signaling molecules on early human pituitary development.
Article in Journal of molecular histology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice†.Biology of reproduction · 2021Article
- Epidemiology and etiopathogenesis of pituitary adenomas.Journal of neuro-oncology · 2014Review
- Anterior pituitary adenomas: inherited syndromes, novel genes and molecular pathways.Expert review of endocrinology & metabolism · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development and differentiation of the human pituitary gland was investigated in 6 human conceptuses 6-9 postovulatory weeks old, using immunohistochemical technique to investigate appearance of different developmental factors, and immunofluorescent double staining technique with Ki-67 to investigate proliferation. In the developing human pituitary gland, different developmental factors appeared in temporally and spatially restricted patterns, thus contributing to formation of different parts of the gland: adenohypophysis, neurohypophysis and associated mesenchyme. Some growth factors were not primarily involved in cell proliferation (TGF-ss, BMP-2/4 and GATA), but in differentiation of pituitary cells: TGF-ss, BMP-2/4 and GATA probably contributed to differentiation of cells in the mesenchyme at earlier stages, while their influence on differentiation of specific cell types in the adenohypophysis increased with development. At later developmental stages, those factors also influenced the differentiation of cells in the neurohypophysis. FGF-8 and FGF-10 probably participated both in the growth and differentiation of pituitary cells: while FGF-8 could act during early developmental stages, FGF-10 participated in the same processes at later stages of pituitary development. Expression of EGF and VEGF indicated their involvement in proliferation of initially differentiated pituitary cells, and in subsequent differentiation of some cell types in the adenohypophysis and neurohypophysis. In the mesenchyme, expression of VEGF might be related to formation of new blood vessels as well. Precise patterns of appearance of growth and transcription factors, and signaling molecules in developing human pituitary gland seem to be important for cell proliferation, differentiation, and normal morphogenesis of the gland.
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Registered trials
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