ArticleCellular and molecular neurobiology2010
GABAergic signaling increases through the postnatal development to provide the potent inhibitory capability for the maturing demands of the prefrontal cortex.
Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 5 citations in OpenAlex.
- Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion.Cellular reprogramming · 2014Article
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4 authors at 1 institution in 1 country.
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Abstract
The developmental profile of the firing patterns and construction of synapse connection were studied in LTS interneurons of prefrontal cortex (PFC) in rats with age (from P7 to P30). We used whole cell patch-clamp recordings to characterize electrophysiological properties of LTS interneurons in PFC at different age stages, including the action potentials (APs), short-term plasticity (STP), evoked excitatory postsynaptic currents (eEPSCs), spontaneous excitatory postsynaptic currents (sEPSC), and spontaneous inhibitory postsynaptic current (sIPSC). The developmental profile of LTS interneurons in our research showed two phases changes. The early phase from P7-P11 to P16-P19 during which the development of individual LTS interneuron dominated and just some simple synaptic connections formed, the synaptic inputs from pyramidal cells play a promoting role for the maturation of LTS interneurons to some extent. This was based on the changes of APs, eEPSCs, and STP such as the curtailment of time course of APs, the increasing facilitation of STP before P16-P19 group. The late phase from P20-P23 to P > 27 during which the function of inhibitory cortex network enhanced and the characters of this inhibitory cortex network continually changed although in the oldest age group (P > 27) in our research. The frequency and amplitude of sIPSC showed continually changes, and at the same age group, the frequency ratios and amplitude ratios of sIPSC was higher than that of sEPSC. Our study showed a foundation to clarify mechanisms underlying the evolution in time of intrinsic neuronal membrane properties and their important roles in balancing the cortex network, providing an academic foundation for the pathological researching on some psychiatric and neurological disorders.
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