ArticleCellular and molecular life sciences : CMLS2010
Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 145 citations in OpenAlex.
- Larval debridement therapy for diabetes-related foot ulcers: Evidence, mechanisms and practical guidance.Clinical medicine (London, England) · 2026Review
- The impact of age and insects factors on cadaver microbial communities and application to postmortem interval Estimation.International journal of legal medicine · 2026Article
- Article
- Machine learning-based text mining for cutaneous myiasis and potential value of an accidental maggot therapy for complicated skin and soft tissue infection with sepsis.Frontiers in cellular and infection microbiology · 2025Article
- Comparative analysis of the antimicrobial activity of larval secretions and excretions from Calliphora vicina and Sarconesiopsis magellanica (Diptera: Calliphoridae)Biomedica : revista del Instituto Nacional de Salud · 2022Article
- Inhibition of Zoonotic Pathogens Naturally Found in Pig Manure by Black Soldier Fly Larvae and Their Intestine Bacteria.Insects · 2022Article
- Microbiome pattern of Lucilia sericata (Meigen) (Diptera: Calliphoridae) and feeding substrate in the presence of the foodborne pathogen Salmonella enterica.Scientific reports · 2021Article
- Antimicrobial Peptides Derived From Insects Offer a Novel Therapeutic Option to Combat Biofilm: A Review.Frontiers in microbiology · 2021Review
- Characterising four Sarconesiopsis magellanica (Diptera: Calliphoridae) larval fat body-derived antimicrobial peptides.Memorias do Instituto Oswaldo Cruz · 2021Article
- Clinical study of Maggot therapy for Fournier's gangrene.International wound journal · 2020Article
- Parasite-bacteria interrelationship.Parasitology research · 2020Review
- Proline-Rich Antimicrobial Peptides in Medicinal Maggots ofFrontiers in pharmacology · 2020Article
- New Insights Into Culturable and Unculturable Bacteria Across the Life History of Medicinal MaggotsFrontiers in microbiology · 2020Article
- Sarconesin II, a New Antimicrobial Peptide Isolated fromMolecules (Basel, Switzerland) · 2019Article
- Molecular characterization of theAIMS genetics · 2019Article
- Investigation of antimicrobial effects of treatedIranian journal of microbiology · 2018Article
- Pharmacological Properties of the Medical Maggot: A Novel Therapy Overview.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Sarconesin:Frontiers in microbiology · 2018Article
- Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus.Scientific reports · 2017Article
- Insect Artifacts Are More than Just Altered Bloodstains.Insects · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel homologue of insect defensin designated lucifensin (Lucilia defensin) was purified from the extracts of various tissues (gut, salivary glands, fat body, haemolymph) of green bottle fly (Lucilia sericata) larvae and from their excretions/secretions. The primary sequence of this peptide of 40 residues and three intramolecular disulfide bridges was determined by ESI-QTOF mass spectrometry and Edman degradation and is very similar to that of sapecin and other dipteran defensins. We assume that lucifensin is the key antimicrobial component that protects the maggots when they are exposed to the highly infectious environment of a wound during the medicinal process known as maggot therapy. We also believe that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.