ReviewJournal of anesthesia2009
Physiology and pathophysiology at high altitude: considerations for the anesthesiologist.
Review in Journal of anesthesia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05715476 (The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery; Comparison of Anesthesia Parameters and Hemodynamic Changes), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery; Comparison of Anesthesia Parameters and Hemodynamic Changes
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for treating acute high altitude illness.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs.The Cochrane database of systematic reviews · 2017Pooled it
- Nasopharyngeal airway oxygenation enhances safe apnea time in patients at moderately high altitude: a randomized clinical trial.Scientific reports · 2025Trial
- Low-dose esketamine combined with propofol versus fentanyl-propofol for preventing hypoxemia during gastroscopy sedation in high-altitude residents: a randomized controlled trial.BMC anesthesiology · 2025Trial
- The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude.Drug design, development and therapy · 2024Trial
- Spinal anaesthesia at low and moderately high altitudes: a comparison of anaesthetic parameters and hemodynamic changes.BMC anesthesiology · 2015Trial
- Evaluation of the impact of high altitude on pre-hospital anaesthetic administration: a scoping review.BJA open · 2026Review
- Dysregulation of metabolites and high-altitude illnesses development under plateau conditions.Frontiers in physiology · 2025Review
- Remote ischemic preconditioning enhances aerobic performance by accelerating regional oxygenation and improving cardiac function during acute hypobaric hypoxia exposure.Frontiers in physiology · 2022Article
- Anesthesia of a high-altitude area inhabitant who underwent aortic dissection emergency surgery in a low-altitude area.The Journal of international medical research · 2020Article
- High-altitude illness: Management approach.Turkish journal of emergency medicine · 2019Review
- Total intravenous anesthesia produces outcomes superior to those with combined intravenous-inhalation anesthesia for laparoscopic gynecological surgery at high altitude.The Journal of international medical research · 2017Article
- High altitude increases the expression of hypoxia-inducible factor 1α and inducible nitric oxide synthase with intest-inal mucosal barrier failure in rats.International journal of clinical and experimental pathology · 2015Article
- Ambulatory and central haemodynamics during progressive ascent to high-altitude and associated hypoxia.Journal of human hypertension · 2014Article
- Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia.Behavioural brain research · 2014Article
- Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude.Medical gas researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Millions of people live in, work in, and travel to areas of high altitude (HA). Skiers, trekkers, and mountaineers reach altitudes of 2500 m to more than 8000 m for recreation, and sudden ascents to high altitude without the benefits of acclimatization are increasingly common. HA significantly affects the human body, especially the cardiovascular and pulmonary systems, because of oxygen deprivation due to decreased ambient barometric pressure. Rapid ascents may lead to high-altitude diseases that sometimes have fatal consequences. Other factors, such as severe cold, dehydration, high winds, and intense solar radiation, increase the morbidity of patients at HA. Anesthesiologists working in or visiting areas of higher elevations should become familiar with the human physiology, altered pharmacology, and disease pattern of HA.
Indexed as
Identifiers
19921365What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.