ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
Pharmaceutical interventions facilitate premedication and prevent opioid-induced constipation and emesis in cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial.The oncologist · 2018Trial
- Article
- Dose-dependent association of naldemedine and magnesium oxide in the management of opioid-induced constipation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Pharmacists' Behavioral Changes after Attending a Multi-Prefectural Palliative Care Education Program.Pharmacy (Basel, Switzerland) · 2024Article
- Constipation Severity and Quality of Life among Patients with Cancer Who Received Prophylactic Laxatives: Quasi-Experimental Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Laxative co-medication and changes in defecation patterns during opioid use.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2019Observational
- Incidence of opioid-induced constipation in Japanese patients with cancer pain: A prospective observational cohort study.Cancer medicine · 2019Observational
- Antacid attenuates the laxative action of magnesia in cancer patients receiving opioid analgesic.The Journal of pharmacy and pharmacology · 2016Article
- Oxycodone/Naloxone: role in chronic pain management, opioid-induced constipation, and abuse deterrence.Pain and therapy · 2014Article
- Influence of pharmaceutical care on the delayed emesis associated with chemotherapy.International journal of clinical pharmacy · 2014Article
- Effect of Prophylactic Anti-emetics on Opioid-induced Nausea and Vomiting: A Retrospective Observational Cohort Study.In vivo (Athens, Greece)Observational
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpioid analgesics possess a number of side effects, among which constipation and nausea/vomiting occur most frequently. Although pretreatment with laxatives and antiemetics for the prophylaxis of opioid-induced constipation and nausea/vomiting, respectively, is recommended, such side effects are still a matter of concern in clinical setting.
methodsWe first surveyed the prevalence of premedication in 83 cancer patients who took opioid analgesics and the incidence of such side effects. Subsequently, intervention was carried out to promote premedication, and the effectiveness of the intervention was evaluated in 107 patients.
resultsProphylactic treatment with laxatives and antiemetics were conducted in 57% and 52%, respectively. The most frequently prescribed laxatives and antiemetics were magnesium oxide in combination with pantethine, a mild stimulant laxative, and prochlorperazine, respectively. The lack of premedication increased the risk of constipation (odds ratio, 5.25; 95% confidence intervals, 1.93-14.31; p = 0.001) and vomiting (4.67, 1.04-21.04; p = 0.045). Intervention such as provision of drug information to physicians, verification of prescription orders, and instructions to patients increased the rates of prophylactic medications to 93% (p < 0.001) for laxatives and 81% (p < 0.001) for antiemetics. The incidence of side effects was lowered from 36% to 9% (p < 0.001) for constipation, from 28% to 17% for nausea (p = 0.077), and from 16% to 4% for vomiting (p = 0.0085).
conclusionIntervention to promote prophylactic medication was highly effective in reducing the risk of opioid-induced constipation and nausea/vomiting.
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