ArticleHuman genetics2010
The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study.
Article in Human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The association of genetic variants of type 2 diabetes with kidney function.Kidney international · 2012Pooled it
- The MYH9/APOL1 region and chronic kidney disease in European-Americans.Human molecular genetics · 2011Pooled it
- A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation.Kidney research and clinical practice · 2023Article
- Kidney podocyte-associated gene polymorphisms affect tacrolimus concentration in pediatric patients with refractory nephrotic syndrome.The pharmacogenomics journal · 2020Article
- Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene.Medicine · 2020Observational
- Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients.International journal of nephrology · 2019Article
- Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people.International urology and nephrology · 2015Observational
- African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era.World journal of nephrology · 2015Review
- Generalization of associations of kidney-related genetic loci to American Indians.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- MYH9 and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population.PloS one · 2014Article
- APOL1 variants and kidney disease in people of recent African ancestry.Nature reviews. Nephrology · 2013Article
- Pathogenesis and therapy of focal segmental glomerulosclerosis: an update.Pediatric nephrology (Berlin, Germany) · 2011Review
- The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.Nature reviews. Nephrology · 2011Review
- Genetics of chronic kidney disease.Nephron. Clinical practice · 2011Article
- A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.Kidney international · 2010Article
- Genetic contribution and associated pathophysiology in end-stage renal disease.The application of clinical genetics · 2010Article
- Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes.Seminars in dialysisReview
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans. Whether these associations are also present among American Indian individuals is unknown. To evaluate the role of genetic polymorphisms in the MYH9 gene on kidney disease in American Indians, we genotyped 25 SNPs in the MYH9 gene region in 1,119 comparatively unrelated individuals. Four SNPs failed, and one SNP was monomorphic We inferred haplotypes using seven SNPs within the region of the previously described E haplotype using Phase v2.1. We studied the association between 20 MYH9 SNPs with kidney function (estimated glomerular filtration rate, eGFR) and CKD (eGFR\60 ml/min/1.73 m(2) or renal replacement therapy or kidney transplant) using age-, sex- and center-adjusted models and measured genotyped within the variance component models. MYH9 SNPs were not significantly associated with kidney traits in additive or recessive genetic adjusted models. MYH9 haplotypes were also not significantly associated with kidney outcomes. In conclusion, common variants in MYH9 polymorphisms may not confer an increased risk of CKD in American Indian populations. Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.