ReviewPflugers Archiv : European journal of physiology2010
K(ATP) channelopathies in the pancreas.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Association of KCNJ11 rs5219 polymorphism with risk of type 2 diabetes and its cardiovascular and renal complications in Noakhali, Bangladesh.Scientific reports · 2025Article
- CaFrontiers in endocrinology · 2024Review
- Personalized Therapeutics for KAnnual review of pharmacology and toxicology · 2023Review
- Early Effects of Metabolic Syndrome on ATP-Sensitive Potassium Channels from Rat Pancreatic Beta Cells.Metabolites · 2022Article
- Comparison of KHandbook of experimental pharmacology · 2021Article
- Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures.Molecular and cellular endocrinology · 2020Review
- Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets.Physiological reports · 2019Article
- The role of membrane excitability in pancreatic β-cell glucotoxicity.Scientific reports · 2019Article
- Contribution of systemic inflammation to permanence of KAmerican journal of physiology. Endocrinology and metabolism · 2018Article
- A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel.The Journal of general physiology · 2018Article
- Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.Pediatric diabetes · 2017Article
- Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.Trends in endocrinology and metabolism: TEM · 2012Review
- Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.Diabetes · 2011Article
- Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations.Circulation. Arrhythmia and electrophysiology · 2011Article
- Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Acta pharmacologica Sinica · 2011Review
- Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11.Reviews in endocrine & metabolic disorders · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic beta-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.